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Establishment of real time dose evaluation system for 3D image guided interstitial brachytherapy of oral cancer

Research Project

Project/Area Number 16K11534
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionOsaka Dental University

Principal Investigator

AKIYAMA Hironori  大阪歯科大学, 歯学部, 講師 (20448111)

Co-Investigator(Kenkyū-buntansha) 吉田 謙  大阪医科大学, 医学部, 准教授 (10463291)
山崎 秀哉  京都府立医科大学, 医学(系)研究科(研究院), 教授 (50301263)
古妻 理之  独立行政法人国立病院機構大阪医療センター(臨床研究センター), 研究員 (00641870)
辻本 豊  独立行政法人国立病院機構大阪医療センター(臨床研究センター), 研究員 (90773135)
隅田 伊織  大阪大学, 医学系研究科, 助教 (10425431)
門前 一  近畿大学, 医学部, 准教授 (10611593)
田中 英一  独立行政法人国立病院機構大阪医療センター(臨床研究センター), 研究員 (10324774)
武中 正  京都府立医科大学, 医学(系)研究科(研究院), 助教 (80626771)
清水谷 公成  大阪歯科大学, 歯学部, 教授 (80121820)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords口腔癌 / 小線源治療 / 人体等価材 / 3Dプリンタ / ファントム / 実測 / 不均質補正シミュレーション / 舌癌 / 組織内照射 / 人体等価 / リアルサイズ / 組織等価 / リアルタイム線量計測 / 3Dプリンタ / テーラーメイド治療 / 画像誘導 / 線量実測 / 蛍光線量計 / リアルタイム / 線量脛側
Outline of Final Research Achievements

The following research was performed for accurate dose evaluation in oral cancer brachytherapy.
1. To produce real size phantom with material that respose radiation the same as human body (human body equivalent material) we developed mould using 3D printer and material for the phantom.
2. For the research using human body equivalent material, we conducted actual measurement and accurate simulation. Specifically, accurate dose calculations for actual patients were performed using simulation software available on a commercial basis. Furthermore, the effect of the mandible shielding material was measured and simulated.

Academic Significance and Societal Importance of the Research Achievements

口腔癌の小線源治療の問題点は、1.手技が煩雑であること。2.人体をすべて水とみなして線量計算がされており、不正確であることである。本研究の結果.両者を一気に解決できることが示された。すなわち、1を人体等価リアルサイズファントムを利用して事前に手技のシミュレーションを行うことで大幅に改善し、2を実測と正確なシミュレーション計算を行うことで解決する。この結果、本手技が広く用いられることや、腫瘍などの実際の正確な線量が判明することが期待される。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (10 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 10 results,  Open Access: 9 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Int'l Joint Research] National Institute of Oncology(ハンガリー)

    • Related Report
      2018 Research-status Report
  • [Journal Article] A new implant device to prevent edema-associated underdosage in high-dose-rate interstitial brachytherapy of mobile tongue cancer.2019

    • Author(s)
      Yoshida K, Kotsuma T, Akiyama H, Yamazaki H, Takenaka T, Masui K, Tsujimoto Y, Murakami N, Uesugi Y, Shimbo T, Yoshikawa N, Yoshioka H, Nakata M, Arika T, Takaoka Y, Tanaka E, Tselis N.
    • Journal Title

      J Contemp Brachytherapy

      Volume: 11 Issue: 6 Pages: 573-8

    • DOI

      10.5114/jcb.2019.91225

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Estimation of radiation shielding ability in electron therapy and brachytherapy with real time variable shape tungsten rubber2019

    • Author(s)
      Monzen Hajime、Tamura Mikoto、Kijima Kenta、Otsuka Masakazu、Matsumoto Kenji、Wakabayashi Kazuki、Choi Min-Geon、Yoon Do-Kun、Doi Hiroshi、Akiyama Hironori、Nishimura Yasumasa
    • Journal Title

      Physica Medica

      Volume: 66 Pages: 29-35

    • DOI

      10.1016/j.ejmp.2019.09.233

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Image guided high-dose-rate brachytherapy versus volumetric modulated arc therapy for head and neck cancer: A comparative analysis of dosimetry for target volume and organs at risk2018

    • Author(s)
      Akiyama H, Pesznyak C, Bela D, Ferenczi O, Major T, Polgar C, Takacsi-Nagy Z
    • Journal Title

      Radiology and Oncology

      Volume: 52 Issue: 4 Pages: 461-467

    • DOI

      10.2478/raon-2018-0042

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dose-volume analysis of target volume and critical structures in computed tomography image-based multicatheter high-dose-rate interstitial brachytherapy for head and neck cancer2017

    • Author(s)
      Akiyama H, Major T, Polgr C, Takacsi-Nagy Z
    • Journal Title

      J Contemp Brachytherapy

      Volume: 9 Issue: 6 Pages: 553-560

    • DOI

      10.5114/jcb.2017.72581

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The role of computed tomography and magnetic resonance imaging in diagnosing clear cell ameloblastoma: A case report2017

    • Author(s)
      Gamoh Shoko、Wato Masahiro、Akiyama Hironori、Tsuji Kaname、Ishikawa Hiroki、Naruse Kaori、Yoshida Hiroaki、Morita Shosuke、Tanaka Akio、Shimizutani Kimishige
    • Journal Title

      Oncology Letters

      Volume: 14 Pages: 7257-7261

    • DOI

      10.3892/ol.2017.7116

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brachytherapy for Buccal Cancer: From Conventional Low Dose Rate (LDR) or Mold Technique to High Dose Rate Interstitial Brachytherapy (HDR-ISBT)2017

    • Author(s)
      Kotsuma T, Yamazaki H, Masui K, Yoshida K, Shimizutani K, Akiyama H, Murakami S, Isohashi F, Yoshioka Y, Ogawa K, Tanaka E
    • Journal Title

      Anticancer Research

      Volume: 37 Issue: 12 Pages: 6887-6892

    • DOI

      10.21873/anticanres.12151

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Calcifying cystic odontogenic tumor accompanied by a dentigerous cyst: A case report2017

    • Author(s)
      Gamoh S、Akiyama H、Furukawa C、Matsushima Y、Iseki T、Wato M、Tanaka A、Morita S、Shimizutani K.
    • Journal Title

      Oncology Letters

      Volume: 14 Pages: 5785-5790

    • DOI

      10.3892/ol.2017.6993

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Edema worsens target coverage in high-dose-rate interstitial brachytherapy of mobile tongue cancer: a report of two cases.2017

    • Author(s)
      Yoshida K, Yamazaki H, Kotsuma T, Akiyama H, Takenaka T, Masui K, Yoshioka Y, Uesugi Y, Shimbo T, Yoshikawa N, Yoshioka H, Arika T, Tanaka E, Narumi Y.
    • Journal Title

      J Contemp Brachytherapy

      Volume: 9 Pages: 66-70

    • DOI

      10.5114/jcb.2017.65163

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Non-contrast computed tomography and magnetic resonance imaging features of mucoepidermoid carcinoma in the salivary glands2017

    • Author(s)
      Gamoh Shoko、Akiyama Hironori、Tsuji Kaname、Nakazawa Tetsuro、Morita Shosuke、Tanaka Akio、Shimizutani Kimishige
    • Journal Title

      Oral Radiology

      Volume: 34 Issue: 1 Pages: 24-30

    • DOI

      10.1007/s11282-017-0281-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gas gangrene in the deep spaces of the head and neck visualized on computed tomography images2017

    • Author(s)
      Gamoh Shoko、Tsuji Kaname、Maruyama Hugo、Hamada Hiroyuki、Akiyama Hironori、Toda Isumi、Wang Pao-Li、Morita Shosuke、Shimizutani Kimishige
    • Journal Title

      Oral Radiology

      Volume: 34 Issue: 1 Pages: 83-87

    • DOI

      10.1007/s11282-017-0277-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 舌癌高線量率組織内照射における 下顎骨遮蔽材の腫瘍や顎骨線量への影響2019

    • Author(s)
      秋山広徳 吉田謙 古妻理之 山崎秀哉 増井浩二 隅田伊織 門前一 武中正 奥田大樹 辻本豊 吉岡裕人 新保大樹 田中英一 小滝真也 清水谷公成
    • Organizer
      第43回日本頭頸部癌学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 舌癌高線量率組織内照射後急性期粘膜反応からみた周術期口腔機能2018

    • Author(s)
      秋山広徳、 森 悠衣、 覚道健治、 中嶋正博、 小滝真也、 四井資隆、 清水谷公成
    • Organizer
      第32回日本口腔リハビリテーション学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 口唇癌画像誘導高線量率組織内照射法の初期経験-治療成績とdose-volume-histogram-2018

    • Author(s)
      秋山広徳, 清水谷公成
    • Organizer
      第36回 日本口腔腫瘍学会 総会・学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] アルツハイマー病患者に発生した頸部深間隙ガス壊疽の一例2017

    • Author(s)
      秋山広徳,蒲生祥子,四井資隆,板垣恵輔,上田恵子,小林篤央,清水谷公成
    • Organizer
      第22回 日本歯科放射線学会 臨床画像大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 同一CTデータを用いた頭頸部癌画像誘導小線源治療と強度変調放射線治療の線量分布比較2017

    • Author(s)
      秋山広徳,Pesznyk Csilla,Bela Dalma, ,Major Tibor, Polgr Csaba ,吉田謙,古妻理之,清水谷君公成,Takcsi-Nagy Zoltan
    • Organizer
      第30回 日本放射線腫瘍学会 学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Dose volume analysis of target and critical structures in CT image based head and neck multicatheter high-dose-rate interstitial brachytherapy.2017

    • Author(s)
      Hironori Akiyama, Tibor Major, Zoltan Taacsi-Nagy, Janos Fodor, Csaba Polgr.
    • Organizer
      Hungarian Society of Radiation Oncology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] Case based review 画像診断に強くなる 顎口腔領域の疾患 読影のポイントから病理診断,治療方針まで2017

    • Author(s)
      金田 隆,久山佳代,浅海淳一,新井嘉則,荒木正夫,有地榮一郎,有地淑子,飯塚紀仁,泉雅浩,伊東浩太郎,井上孝,岡田康男,川島雄介,倉林亨,小宮正道,酒井修,櫻井孝,澤田絵里,秋山広徳,清水谷公成
    • Total Pages
      296
    • Publisher
      永末書店
    • ISBN
      9784816013249
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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