Establish of molecullar biological strategy to MRONJ by glucose metabolism

• Project/Area Number: 16K11607
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Kyushu Dental College
• Principal Investigator: Tsuka Shintaro 九州歯科大学, 歯学部, 助教 (20759386)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 骨代謝 / 糖代謝 / MRONJ / 歯科インプラント / 骨粗鬆症 / 糖尿病

Outline of Final Research Achievements

MRONJ,which proceeds with dental treatment,is a major problem for osteoporosis-treated patients who are receiving bisphosphonate (BP). We focused on the relationship between bone metabolism and general glucose metabolism, and aimed to clarify the effect of BP on jaw bone healing delay after tooth extraction using a diabetes drug. Three-dimensional structural evaluation of the jaw bone after tooth extraction showed significant healing improvement of the tooth extraction socket in the experimental group. Furthermore, when the necrotic bone area was evaluated, the experimental group showed a significantly lower value. These results suggest that the risk of MRONJ for tooth extraction and implant treatment can be controlled by drug therapy.

Academic Significance and Societal Importance of the Research Achievements

近年，BP 製剤とは異なる作用機序により骨吸収を抑制する薬剤でも，同頻度で顎骨壊死が発症するとの報告がある．BP 製剤自体の問題でなく，それらが持つ，骨吸収抑制作用に起因すると推測される．顎骨壊死の詳細な機序については，未だ明らかにされていないが，本研究で糖代謝の関連性が判明すれば，MRONJ の病態解析，新規骨吸収阻害創薬が可能となり，インプラント治療に限らず，BP 製剤がもたらす歯科治療への弊害を軽減することが期待できる．

Research Products

• [Presentation] 糖代謝関連薬剤は骨吸収抑制剤による 顎骨治癒遅延を改善できるか？ (2019)
  • Author(s): 柄慎太郎
  • Organizer: 日本口腔インプラント学会第36回九州支部学術大会
• [Presentation] Corticosteroid Treatment Affects Mouse Submandibular Gland Function (2017)
  • Author(s): Yuichiro Kusuda, Yusuke Kondo, Takashi Munemasa, Yuta Miyagi, Shintaro Tsuka, Taro Mukaibo, Chihiro Masaki, Ryuji Hosokawa
  • Organizer: The 95th General Session & Exhibition of the IADR
  • Place of Presentation: San Francisco
  • Year and Date: 2017-03-22
  • Int'l Joint Research
• [Presentation] 老化因子が骨代謝におよぼす影響の細胞生物学的解析 (2017)
  • Author(s): 青沼史子，竹内弘，柄慎太郎，近藤祐介，友枝圭，石田秀幸，正木千尋， 細川隆司
  • Organizer: 第34回公益社団法人日本口腔インプラント学会九州支部学術大会
  • Place of Presentation: 熊本
  • Year and Date: 2017-01-21
• [Presentation] Low-intensity pulsed ultrasound snhanced wound healing in gingival epithelial cells (2016)
  • Author(s): Yujiro Iwanabe, Shintaro Tsuka, Akiko Tamura, Saori Misumi, Taro Mukaibou, Yusuke Kondo, Chihiro Masaki, Ryuji Hosokawa
  • Organizer: 25th annual scientific meeting of the european association for osseointegration
  • Place of Presentation: Paris
  • Year and Date: 2016-09-30
  • Int'l Joint Research
• [Presentation] 老化が骨代謝におよぼす影響の細胞生物学的分析 (2016)
  • Author(s): 青沼史子，柄慎太郎，田村暁子，三隅沙緒理，近藤祐介，正木千尋，竹内弘，細川隆司
  • Organizer: 第46回公益社団法人日本口腔インプラント学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2016-09-17
• [Presentation] Modification of osteoclast differentiation by the complement factor (2016)
  • Author(s): Fumiko Aonuma, Sen Higashi, Shintaro Tsuka, Tomoko Ohsumi, Ryuji Hosokawa, Hiroshi Takeuchi
  • Organizer: ASIA-PACIFIC CONFERENCE
  • Place of Presentation: 福岡
  • Year and Date: 2016-05-11
  • Int'l Joint Research
• [Book] 歯科医療 (2016)
  • Author(s): 正木千尋，柄慎太郎，田村暁子，細川隆司
  • Total Pages: 144
  • Publisher: 第一歯科出版