Bone regenerative therapy using Escherichia coli-derived rhBMP-2 adsorbed in beta-TCP.
Project/Area Number |
16K11624
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Prosthodontics/ Dental materials science and
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Research Institution | Okayama University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
大野 充昭 岡山大学, 医歯薬学総合研究科, 助教 (60613156)
窪木 拓男 岡山大学, 医歯薬学総合研究科, 教授 (00225195)
大野 彩 (木村彩) 岡山大学, 大学病院, 助教 (20584626)
笈田 育尚 岡山大学, 医歯薬学総合研究科, 助教 (50625720)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | BMP-2 / 骨再生 / 大腸菌 / rhBMP-2 / 人工骨 / 再生療法 |
Outline of Final Research Achievements |
Bone regeneration using BMP-2 is expected to have the highest therapeutic effect, but there is no BMP-2 product approved in Japan. We succeeded to develop the BMP-2 using E. coli system and it was clarified that the combination of E. coli-BMP-2 and the already approved biodegradable artificial bone, β-tricalcium phosphate (β-TCP), strongly induces bone formation in socket preservation model in dog.
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Academic Significance and Societal Importance of the Research Achievements |
開発品が日本において承認されれば,十分な骨量がないためにインプラント治療をあきらめていた多くの患者に福音となることは間違いない.将来的にはMRONJ,インプラント周囲炎,口蓋裂,腫瘍摘出後の顎骨再建など,歯科領域だけでも多様な用途が考えられる.さらに,難治性骨折など整形外科領域での応用にも繋がる大変有意義な成果となることに疑う余地はなく,本申請の技術が世界に向けて発信されれば,日本発の創薬として,大きなインパクトがあると考える.
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Report
(4 results)
Research Products
(13 results)
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[Presentation] Novel function of BMP-2 to prohibit bone formation in marrow environment.2018
Author(s)
Nguyen HT, Ono M, Oida Y, Hara ES, Komori T, Akiyama K, Nguyen HTT, Aung KT, Pham HT, Oohashi T, Kuboki T
Organizer
The American Society of Bone and Mineral Research.
Related Report
Int'l Joint Research
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[Presentation] Marrow cells inhibits BMP-2-induced bone formation in the marrow.2018
Author(s)
Nguyen HT, Ono M, Oida Y, Hara ES, Komori T, Akiyama K, Nguyen HTT, Aung KT, Pham HT, Tosa I, Takarada T, Matsuo T, Mizoguchi T, Oohashi T, Kuboki T
Organizer
Conference in Science and Education of OdontoStomatology.
Related Report
Int'l Joint Research / Invited
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