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Does contribute the super hydrophilic treatment to soft tissue adhesion?

Research Project

Project/Area Number 16K11660
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTokyo Dental College

Principal Investigator

Yoshinari Masao  東京歯科大学, 歯学部, 客員教授 (10085839)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords口腔インプラント / 生物学的封鎖 / 超親水性処理 / ラミニン332 / 水晶発振子マイクロバランス(QCM) / X線光電子分光分析(XPS) / QCM / XPS / タンパク質吸着 / 上皮細胞 / 線維芽細胞 / インプラント / 軟組織接着
Outline of Final Research Achievements

The superhydrophilic surface modification is reported to enhance the adsorption of the proteins to titanium. This study aimed to evaluate the binding behavior of LN332 on the surface-modified Ti with superhydrophilicity, In addition, the mechanism of enhancing adsorption of LN332 is considered by the surface analyses. The atmospheric-pressure plasma treatment (Ti-Plasma) and ultraviolet treatment (Ti-UV) as a superhydrophilic treatment were performed to the titanium sensor that was designed for quartz crystal microbalance (QCM-D) apparatus. Untreated gold (Au-Air) or titanium sensor (Ti-Air) were used as a control. Adsorption properties of LN332 were assessed using a QCM-D method. In addition, surface characteristics with X-ray photoelectron spectroscopy (XPS) and SEM observation are performed using LN332-adsrobed specimens.The results suggested that the superhydrophilic modifications may promote the adhesion of LN332 to titanium.

Academic Significance and Societal Importance of the Research Achievements

口腔インプラントに対する低温大気圧プラズマ処理は、処理時間が10秒程度と短時間で超親水性を付与することができ、インプラント表面への上皮接着能や上皮下結合組織接着能を向上させ、ひいてはインプラント周囲上皮の下方増殖および細菌の侵入を抑制する生物学的閉鎖を達成できる可能性があることが示唆される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (29 results)

All 2019 2018 2017 2016

All Journal Article (18 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 18 results,  Open Access: 12 results,  Acknowledgement Compliant: 3 results) Presentation (8 results) (of which Int'l Joint Research: 5 results,  Invited: 4 results) Book (3 results)

  • [Journal Article] Wear properties of esthetic dental materials against translucent zirconia2019

    • Author(s)
      Hayashi S, Homma S, Takanashi T, Hirano T, Yoshinari M, Yajima Y
    • Journal Title

      Dental Materials Journal

      Volume: 38 Issue: 2 Pages: 250-256

    • DOI

      10.4012/dmj.2018-133

    • NAID

      130007628986

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2019-03-28
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Study on bone quality in the human mandible-Alignment of biological apatite crystallites2019

    • Author(s)
      Furukawa T, Matsunaga S, Morioka T, Nakano T, Abe S, Yoshinari M, Yajima Y
    • Journal Title

      J. Biomed. Mater. Res. Part B

      Volume: 107 Pages: 838-846

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] <b>Effect of Superhydrophilic Treatment on Adsorption of Laminin 332 to Titanium</b>2018

    • Author(s)
      柴垣博一, 野本秀材, 野村智義, 老川秀紀,吉成正雄
    • Journal Title

      Journal of Japanese Society of Oral Implantology

      Volume: 31 Issue: 3 Pages: 208-215

    • DOI

      10.11237/jsoi.31.208

    • NAID

      130007502548

    • ISSN
      0914-6695, 2187-9117
    • Year and Date
      2018-09-30
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of occlusal groove on abutment, crown thickness, and cement-type on fracture load of monolithic zirconia crowns2018

    • Author(s)
      Tsuyuki Y, Sato T, Nomoto S, Yotsuya M, Koshihara T, Takemoto S, Yoshinari M
    • Journal Title

      Dental Materials Journal

      Volume: 37 Issue: 5 Pages: 843-850

    • DOI

      10.4012/dmj.2017-350

    • NAID

      130007492946

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2018-09-27
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corrosion behavior of titanium in response to sulfides produced by Porphyromonas gingivalis2018

    • Author(s)
      Harada Rino、Kokubu Eitoyo、Kinoshita Hideaki、Yoshinari Masao、Ishihara Kazuyuki、Kawada Eiji、Takemoto Shinji
    • Journal Title

      Dent Mater

      Volume: 34 Issue: 2 Pages: 183-191

    • DOI

      10.1016/j.dental.2017.10.004

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influence of grade and surface topography of commercially pure titanium on fatigue properties2018

    • Author(s)
      Suzuki K, Takano T, Takemoto S, Ueda T, Yoshinari M, Sakurai K.
    • Journal Title

      Dental Materials Journal

      Volume: 37 Issue: 2 Pages: 308-316

    • DOI

      10.4012/dmj.2017-125

    • NAID

      130006588839

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bone marrow stromal cells from low-turnover osteoporotic mouse model are less sensitive to the osteogenic effects of fluvastatin.2018

    • Author(s)
      Y Oda, H Sasaki, T Miura, T Takanashi, Y Furuya, M Yoshinari, Y Yajima
    • Journal Title

      PLOS ONE

      Volume: 13(8) Issue: 8 Pages: 1-14

    • DOI

      10.1371/journal.pone.0202857

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influence of lyophilization factors and gelatin concentration on pore structures of atelocollagen/gelatin sponge biomaterial2017

    • Author(s)
      L Yang, K Tanabe, T Miura, M Yoshinari, S Takemoto, S Shintani, M Kasahara
    • Journal Title

      Dental Materials Journal

      Volume: 36 Issue: 4 Pages: 429-437

    • DOI

      10.4012/dmj.2016-242

    • NAID

      130005865054

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Release properties of atelocollagen-gelatin complexes as carriers for local administration of fluvastatin2017

    • Author(s)
      K Kida, K Tanabe, H Sasaki, Y Furuya, T Miura, M Yoshinari, Y Yajima
    • Journal Title

      Dental Materials Journal

      Volume: 36 Issue: 4 Pages: 408-414

    • DOI

      10.4012/dmj.2016-179

    • NAID

      130005865057

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Alignment of Biological Apatite Crystallites in Peri-Implant Bone of Beagles2017

    • Author(s)
      Kento Odaka, Satoru Matsunaga, Massaki Kasahara, Takayoshi Nakano, Masao Yoshinari and Shinichin Abe
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 58 Issue: 1 Pages: 107-112

    • DOI

      10.2320/matertrans.M2016228

    • NAID

      130006776978

    • ISSN
      1345-9678, 1347-5320
    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Debridement effect on periodontal pathogen Porphyromonas gingivalis cultured on titanium by application of atmospheric-pressure plasma2017

    • Author(s)
      T Miura, M Egawa, T Ito, T Eguro, K Tanabe, M Yoshinari
    • Journal Title

      Journal of Biomedical Science and Engineering

      Volume: 10(2) Issue: 02 Pages: 51-59

    • DOI

      10.4236/jbise.2017.102006

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hybrid framework with cobalt-chromium alloy and gold cylinder for implant superstructure: Bond strength and corrosion resistance2016

    • Author(s)
      Yoshinari M, Uzawa S, Komiyama Y.
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 60 Issue: 4 Pages: 274-281

    • DOI

      10.1016/j.jpor.2016.01.007

    • NAID

      130005172121

    • ISSN
      1883-1958, 1883-9207
    • Year and Date
      2016-10-25
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influence of sulfide concentration on the corrosion behavior of titanium in a simulated oral environment2016

    • Author(s)
      Harada R, Takemoto S, Kinoshita H, Yoshinari M, Kawada E.
    • Journal Title

      Materials Science & Engineering. C, Materials for Biological Application

      Volume: 62 Pages: 268-273

    • DOI

      10.1016/j.msec.2016.01.065

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Antimicrobial effect of titanium dioxide after ultraviolet irradiation against periodontal pathogen2016

    • Author(s)
      Shirai R, Miura T, Yoshida A, Yoshino F, Ito T, Yoshinari M, Yajima Y
    • Journal Title

      Dental Materials Journal

      Volume: 35 Issue: 3 Pages: 511-516

    • DOI

      10.4012/dmj.2015-406

    • NAID

      130005155189

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of Physicochemical Surface Modifications on Bovine Serum Albumin Adsorption to Tetragonal Zirconia Polycrystal <i>in vitro</i> Through the change of the Zeta Potential2016

    • Author(s)
      N Miyake, T Miura, K Tanabe, R Hisanaga, S Yamashita, T Sato, M Yoshinari
    • Journal Title

      Journal of Oleo Science

      Volume: 65 Issue: 12 Pages: 1003-1010

    • DOI

      10.5650/jos.ess16053

    • NAID

      130005170637

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dynamic cultivation with radial flow bioreactor enhances proliferation2016

    • Author(s)
      Kanda Y, Nishimura I, Sato T, Katayama A, Arano T, Ikada Y, Yoshinari M.
    • Journal Title

      Regenerative Therapy

      Volume: 5 Pages: 17-24

    • DOI

      10.1016/j.reth.2016.06.001

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effects of a multilayered DNA/protamine coating on titanium implants on bone responses2016

    • Author(s)
      Sakurai T, Yoshinari M2, Toyama T3, Hayakawa T4, Ohkubo C
    • Journal Title

      J Biomed Mater Res Part A

      Volume: 104A Issue: 6 Pages: 1500-1509

    • DOI

      10.1002/jbm.a.35679

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influence of eccentric cyclic loading on implant components: Comparison between external joint system and internal joint system2016

    • Author(s)
      Sakamoto K1, Homma S, Takanashi T, Takemoto S, Furuya Y, Yoshinari M, Yajima Y
    • Journal Title

      Dental Materials Journal

      Volume: 35 Issue: 6 Pages: 929-937

    • DOI

      10.4012/dmj.2016-055

    • NAID

      130005171578

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Influence of superhydrophilic treatment to titanium on adsorption of bone-associated cytokine and behavior of osteoblast-like cells2019

    • Author(s)
      Yoshinari M, Takemoto S
    • Organizer
      538th International Conference On Medical, Biological And Pharmaceutical Sciences (ICMBPS)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] メタルフリー・ジルコニアインプラントの可能性2019

    • Author(s)
      吉成正雄
    • Organizer
      日本口腔インプラント学会 第38回関東・甲信越支部学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] インプラント・顎骨埋入材料2018

    • Author(s)
      吉成正雄
    • Organizer
      日本化学会第98春季 「歯学と化学の連携」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] メタルフリー・ジルコニア修復2018

    • Author(s)
      吉成正雄
    • Organizer
      第33回日本歯科産業学会学術講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Effect of surface treatment on wettability of tetragonal zirconia polycrystals (TZP)2018

    • Author(s)
      Yoshinari M
    • Organizer
      19th World Congress on Materials Science and Engineering
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Adsorption Characteristics of Fibronectin and CXCL12 onto Super-hydrophilic Titanium2017

    • Author(s)
      Masao YOSHINARI1,2, Shinji TAKEMOTO1,2, Akio NORO
    • Organizer
      95th General Session & Exhibition of the IADR
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2017-03-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Influence of osteogenic differentiation medium on hMSCs in 3D-culture with radial flow bioreactor2017

    • Author(s)
      Yoshinari M
    • Organizer
      TERMIS (Tissue Engineering and Regenerative Medicine International Society) -EU
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Influence of surface physicochemical modification on wettability of zirconia (TZP) and behaviour of oral keratinocytes2016

    • Author(s)
      Yoshinari M, Takemoto S
    • Organizer
      The International Dental Materials Congress 2016
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2016-11-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] 新編歯科理工学-第6版2019

    • Author(s)
      服部雅之、武本真治、小田 豊、吉成正雄
    • Total Pages
      312
    • Publisher
      学建書院
    • ISBN
      9784762435621
    • Related Report
      2018 Annual Research Report
  • [Book] インプラント材料Q&A 臨床の疑問に答える-マテリアル編2017

    • Author(s)
      吉成正雄
    • Total Pages
      144
    • Publisher
      医歯薬出版
    • ISBN
      9784263461334
    • Related Report
      2017 Research-status Report
  • [Book] インプラント材料Q&A 臨床の疑問に答える-クリニカル編2017

    • Author(s)
      吉成正雄
    • Total Pages
      152
    • Publisher
      医歯薬出版
    • ISBN
      9784263461341
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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