Does contribute the super hydrophilic treatment to soft tissue adhesion?
| Project/Area Number |
16K11660
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 口腔インプラント / 生物学的封鎖 / 超親水性処理 / ラミニン332 / 水晶発振子マイクロバランス（QCM） / X線光電子分光分析（XPS） / QCM / XPS / タンパク質吸着 / 上皮細胞 / 線維芽細胞 / インプラント / 軟組織接着 |
|---|
| Outline of Final Research Achievements |
The superhydrophilic surface modification is reported to enhance the adsorption of the proteins to titanium. This study aimed to evaluate the binding behavior of LN332 on the surface-modified Ti with superhydrophilicity, In addition, the mechanism of enhancing adsorption of LN332 is considered by the surface analyses. The atmospheric-pressure plasma treatment (Ti-Plasma) and ultraviolet treatment (Ti-UV) as a superhydrophilic treatment were performed to the titanium sensor that was designed for quartz crystal microbalance (QCM-D) apparatus. Untreated gold (Au-Air) or titanium sensor (Ti-Air) were used as a control. Adsorption properties of LN332 were assessed using a QCM-D method. In addition, surface characteristics with X-ray photoelectron spectroscopy (XPS) and SEM observation are performed using LN332-adsrobed specimens.The results suggested that the superhydrophilic modifications may promote the adhesion of LN332 to titanium.
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| Academic Significance and Societal Importance of the Research Achievements |
口腔インプラントに対する低温大気圧プラズマ処理は、処理時間が10秒程度と短時間で超親水性を付与することができ、インプラント表面への上皮接着能や上皮下結合組織接着能を向上させ、ひいてはインプラント周囲上皮の下方増殖および細菌の侵入を抑制する生物学的閉鎖を達成できる可能性があることが示唆される。
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Report
(4 results)
Research Products
(29 results)
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[Book] 新編歯科理工学－第6版2019
Author(s)
服部雅之、武本真治、小田 豊、吉成正雄
Total Pages
312
Publisher
学建書院
ISBN
9784762435621
Related Report
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