Identification of molecular mechanisms of volume-regulated ion channels, which regulate cell proliferation in oral cancer
| Project/Area Number |
16K11713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
今井 裕子 九州大学, 大学病院, 助教 (30592688)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 口腔癌細胞 / 細胞増殖 / 容積感受性クロライドチャネル / TMEM16A / LRRC8A / bestrophin-1 / 口腔癌 / bestrophin 1 / 口腔外科学一般 / 口腔扁平上皮癌 / 浸透圧感受性陰イオンチャネル / TRPチャネル |
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| Outline of Final Research Achievements |
Volume-regulated anion channel (VRAC) is expressed in various normal and cancer cells and plays important role in cell volume regulation. Although TMEM16A, LRRC8A and bestrophin-1 (BEST1) are thought to be molecular candidates of VRAC. We have identified that interaction between TMEM16A and LRRC8A composed VRCC, which regulated proliferation in concert with BEST1 in HST-1, human metastatic oral squamous cell carcinoma, cells.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、口腔癌細胞の増殖に関与する新たな分子標的（VRAC: TMEM16AおよびLRRC8A）を見出すことで、新規抗癌剤の開発に寄与することができると考える。特に本研究で用いたVRAC阻害薬であるDCPIBは、血清との結合により効果をなくすという欠点はあるが、転移性口腔癌細胞であるHST-1に効果を示す一方で、正常皮膚角化細胞には全く影響を与えなかったことから、DCPIBの血清結合部位の改変等によるVRAC標的薬の開発が、副作用の少ない（正常細胞に影響のない）新たな抗癌剤に繋がることが考えられた。以上が、本研究成果の学術的意義および社会的意義である。
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Report
(5 results)
Research Products
(94 results)
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[Journal Article] Evaluation of a new ceramic-containing toothbrush bristle. 1. Questionnaire survey on dental hygienist students about its usability and first impressions.2018
Author(s)
Yoneda M, Ishii Ayako, Matsuo T, Omagari S, Suzuki N, Tsuzuki T, Taniguchi Y, Morita H, Koga C, Takahashi Y, Hirofuji T.
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Journal Title
Journal of Oral Hygiene and Health
Volume: 6
Pages: 3-3
Related Report
Peer Reviewed
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[Journal Article] A cace of oral malodor : Improving the motivation of patients by use of bacterial examination.2016
Author(s)
Yoneda M, Suzuki N, Fujimoto A, Ishii A, Yamada K, Masuo Y, Iwamoto T, Haraga M, Koga C, Morita H, Inoue Y, and Hirofuji T
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Journal Title
J Oral Hyg Health
Volume: -
Issue: 2
Pages: 2-2
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Awareness and knowledge of halitosis: Comparison of two grades of dental hygienist students.2016
Author(s)
Inoue E, Yoneda M, Suzuki N, Matsuo T, Ishii A, Haraga M, Hirahashi K, Morita H, Koga C, Inoue Y, Yasukouchi H, and Hirofuji T.
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Journal Title
J Oral Hyg Health
Volume: -
Issue: 05
Pages: 5-5
DOI
Related Report
Peer Reviewed / Open Access
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