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Development of the bone regenerative medicine with the porous carbonate apatite made from calcium sulfate and bone marrow stem cell

Research Project

Project/Area Number 16K11752
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionTokushima Bunri University (2018-2019)
The University of Tokushima (2016-2017)

Principal Investigator

Fujisawa Kenji  徳島文理大学, 保健福祉学部, 教授 (40228979)

Co-Investigator(Kenkyū-buntansha) 宮本 洋二  徳島大学, 大学院医歯薬学研究部(歯学域), 教授 (20200214)
永井 宏和  東北大学, 歯学研究科, 准教授 (50282190)
大江 剛  徳島大学, 病院, 講師 (60432762)
高丸 菜都美  徳島大学, 病院, 助教 (40513031)
石川 邦夫  九州大学, 歯学研究院, 教授 (90202952)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords多孔質炭酸アパタイト / 炭酸アパタイト多孔体 / 冷間等方圧加圧法 / 再生医療
Outline of Final Research Achievements

Porous carbonate apatite(CO3Ap) granules were successfully fabricated maintaining pores corresponding to the size of microfiber. These granules showed good osteoconductivity at 2, 4, and 8 weeks after implantation regardless of pore size. Lager amount of new bone in the whole defect area tended to be formed in the group of porous CO3Ap granules made using microfiber with 50 μm and 120 μm in diameter compared to those of the dense CO3Ap granules group and the group of porous CO3Ap granules made using microfiber with 30 μm and 205 μm in diameter. Also, the amount of new bone in the pores of CO3Ap granules made using microfiber with 120 μm in diameter was significantly largest among the porous CO3Ap granules at 2 weeks after implantation.
It is concluded, therefore, porous carbonate apatite granules may be useful for bone substitute material compared to dense CO3Ap granules, and pore size with 120 μm would be suitable for new bone formation.

Academic Significance and Societal Importance of the Research Achievements

顎骨の欠損や萎縮などの部位に対して骨補填材が移植されるが、異物とならずに自家骨のように吸収され、骨に置換する材料が求められる。われわれは、生体骨に類似した炭酸アパタイトに着目し、炭酸カルシウムを出発物質として、溶解析出反応で低結晶性の炭酸アパタイト硬化体を作製する方法を開発した。これまでは緻密体の材料であっが、これを多孔化することにより速い骨の再生が可能になるとともに、新たな骨再生医療の開発も期待できる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2019 2018

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results)

  • [Journal Article] Fabrication of porous carbonate apatite granules using microfiber and its histological evaluations in rabbit calvarial bone defects.2019

    • Author(s)
      Akita K, Fukuda N, Kamada K, Kudoh K, Kurio N, Tsuru K, Ishikawa K, Miyamoto Y.
    • Journal Title

      Journal of Biomedical Materials Research Part A.

      Volume: 108 Issue: 3 Pages: 709-721

    • DOI

      10.1002/jbm.a.36850

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compositional and histological comparison of carbonate apatite fabricated by dissolution-precipitation reaction and Bio-Oss.2018

    • Author(s)
      Fujisawa K, Akita K, Fukuda N, Kamada K, Kudoh T, Ohe G, Mano T, Tsuru K, Ishikawa K, Miyamoto Y.
    • Journal Title

      Journal of Materials Science: Materials in Medicine

      Volume: 29 Issue: 8 Pages: 121-121

    • DOI

      10.1007/s10856-018-6129-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fabrication and evaluation of carbonate apatite‐coated calcium carbonate bone. substitutes for bone tissue engineering2018

    • Author(s)
      Fujioka‐Kobayashi M, Tsuru K, Nagai H, Fujisawa K, Kudoh T, Ohe G, Ishikawa K, Miyamoto Y.
    • Journal Title

      Journal of tissue engineering and regenerative medicine

      Volume: 12 Pages: 2077-2087

    • DOI

      10.1002/term.2742

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] ハニカム構造を有する炭酸アパタイト多孔体の開発と下顎骨再建への応用2019

    • Author(s)
      工藤景子,福田直志,秋田和也、工藤隆治,大江剛,栗尾奈愛,山村佳子,鎌田久美子,真野隆充,宮本洋二
    • Organizer
      第64回日本口腔外科学会総会・学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ナイロンファイバーを用いた多孔質炭酸アパタイトの開発2018

    • Author(s)
      秋田和也, 福田直志, 大江 剛, 藤澤健司, 眞野隆充, 宮本洋二
    • Organizer
      第72回日本口腔科学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] マイクロファイバーを用いた多孔質炭酸アパタイト顆粒の開発と骨再建への応用2018

    • Author(s)
      秋田和也, 福田直志, 鎌田久美子, 大江 剛, 眞野隆充, 都留寛治, 石川邦夫, 宮本洋二
    • Organizer
      第48回日本口腔インプラント学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] マイクロファイバーを用いた多孔質炭酸アパタイト顆粒の作製およびその骨形成への応用2018

    • Author(s)
      秋田和也, 福田直志, 大江 剛, 眞野隆充, 都留寛治, 石川邦夫, 宮本洋二
    • Organizer
      第40回日本バイオマテリアル学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ナイロンファイバーを用いた多孔質炭酸アパタイトの開発2018

    • Author(s)
      秋田和也,福田直志,大江 剛,藤澤健司,眞野隆充,宮本洋二
    • Organizer
      第72回NPO法人日本口腔科学会学術大会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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