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Planning of a strategy for general anesthesia targeting good wound healing after oral and maxillofacial surgery

Research Project

Project/Area Number 16K11764
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionTokyo Dental College

Principal Investigator

ICHINOHE Tatsuya  東京歯科大学, 歯学部, 教授 (40184626)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords組織血流量 / 組織酸素分圧 / 組織酸素消費量 / 組織酸素代謝 / レミフェンタニル / 血流再分布 / 全身麻酔 / 口腔外科手術
Outline of Final Research Achievements

Redistribution may occur between skin/mucosa and other oral tissues, but not between the tissues supplied by external carotid artery and those by internal carotid artery during remifentanil administration. Remifentanil reduces oral tissue oxygen consumption and thereby proportionally reduces oral tissue blood flow. As a result, oral tissue oxygen tension should be kept unchanged. Changes in arterial carbon dioxide tension do not affect oral tissue oxygen tension during remifentanil administration, and it is suggested that good oxygen metabolism in oral tissues should be maintained during remifentanil administration.

Academic Significance and Societal Importance of the Research Achievements

顎骨に対する手術であれば、レミフェンタニルを用いた全身麻酔に軽度の過換気を併用することで、組織酸素代謝を維持しつつ骨髄血流量を減少させることができるなど、レミフェンタニルの投与速度と換気条件を変化させることによって、良好な組織酸素代謝を維持しつつ組織血流量を減少させ、出血量の軽減に貢献するとともに、手術後に良好な創傷治癒をもたらす全身麻酔法を実施できる可能性が示唆された。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2019 2018 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Decreases in oral tissue blood flow induced by remifentanil are not accompanied by deterioration of oral tissue oxygen tension in rabbits2019

    • Author(s)
      Kobayashi S, Kasahara M, Akiike Y, Matsuura N, Ichinohe T
    • Journal Title

      Journal of Oral and Maxillofacial Surgery

      Volume: 印刷中 Issue: 5 Pages: 965-970

    • DOI

      10.1016/j.joms.2018.12.033

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Remifentanil decreases oral tissue blood flow while maintaining internal carotid artery blood flow during sevoflurane anesthesia in rabbits2018

    • Author(s)
      Hirata A, Kasahara M, Matsuura N, Ichinohe T
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 2 Pages: 354-360

    • DOI

      10.1292/jvms.17-0319

    • NAID

      130006410765

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Influence of changes in end tidal carbon dioxide tension on oral tissue oxygen tension during remifentanil infusion2018

    • Author(s)
      Nakayama A, Akiike Y, Kasahara M, Matsuura N, Ichinohe T
    • Organizer
      15th International Dental Congress on Anesthesia, Sedation and Pain Control (IFDAS2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of 2% lidocaine with 1:80,000 epinephrine on pulpal blood flow and oxygen tension in rabbits2018

    • Author(s)
      Tachibana K, Kasahara M, Matsuura N, Ichinohe T
    • Organizer
      15th International Dental Congress on Anesthesia, Sedation and Pain Control (IFDAS2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] レミフェンタニル投与時の口腔組織酸素分圧の変化2017

    • Author(s)
      小林紗矢香,笠原正貴,秋池由比,橘 継国,松浦信幸,一戸達也
    • Organizer
      第64回日本麻酔科学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] レミフェンタニル投与時の口腔組織酸素分圧の変化2017

    • Author(s)
      小林紗矢香,笠原正貴、秋池由比,中山 藍,橘 継国,松浦信幸,一戸達也
    • Organizer
      第45回日本歯科麻酔学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] レミフェンタニルの投与が兎の内頸動脈血流量と口腔組織血流量の変化に及ぼす影響2016

    • Author(s)
      平田敦司,笠原正貴,一戸達也
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-08-25
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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