Elucidation of the novel mechanism to retard the aging by stem cells from human exfoliated deciduous teeth
| Project/Area Number |
16K11806
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山座 孝義 九州大学, 歯学研究院, 准教授 (80304814)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 乳歯歯髄由来間葉系幹細胞 / カロリー制限 / 小児歯科学 / 間葉系幹細胞 / 老化 / ヒト乳歯幹細胞 |
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| Outline of Final Research Achievements |
The objective of this study is to elucidate the novel mechanism to retard the aging by stem cells from human exfoliated deciduous teeth (SHED). The idea to compare SHED-injective mice and the mice under caloric restriction, which extends the average and maximum lifespan, is the breakthrough foundation of this study to the novel mechanism for the aging. The outputs of this study could give the impression at home and abroad, and be basis of the drug delivery to retard the aging.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果は国内外に大きなインパクトを与えるとともに、アンチエイジング医薬品開発の基盤となりうることが十分に期待される。
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Impaired neurite development associated with mitochondrial dysfunction in dopaminergic neurons differentiated from exfoliated deciduous tooth-derived pulp stem cells of children with autism spectrum disorder.2018
Author(s)
Nguyen HTN, Kato H, Masuda K, Yamaza H, Hirofuji Y, Sato H, Phama T, Takayama F, Sakai Y,Ohga S, Taguchi T, Nonaka K
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Journal Title
Biochem Biophys Rep
Volume: 16
Pages: 24-31
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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