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Elucidation of the novel mechanism to retard the aging by stem cells from human exfoliated deciduous teeth

Research Project

Project/Area Number 16K11806
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthodontics/Pediatric dentistry
Research InstitutionKyushu University

Principal Investigator

Yamaza Haruyoshi  九州大学, 歯学研究院, 准教授 (30336151)

Co-Investigator(Kenkyū-buntansha) 山座 孝義  九州大学, 歯学研究院, 准教授 (80304814)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords乳歯歯髄由来間葉系幹細胞 / カロリー制限 / 小児歯科学 / 間葉系幹細胞 / 老化 / ヒト乳歯幹細胞
Outline of Final Research Achievements

The objective of this study is to elucidate the novel mechanism to retard the aging by stem cells from human exfoliated deciduous teeth (SHED). The idea to compare SHED-injective mice and the mice under caloric restriction, which extends the average and maximum lifespan, is the breakthrough foundation of this study to the novel mechanism for the aging. The outputs of this study could give the impression at home and abroad, and be basis of the drug delivery to retard the aging.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は国内外に大きなインパクトを与えるとともに、アンチエイジング医薬品開発の基盤となりうることが十分に期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (28 results)

All 2018 2017 2016

All Journal Article (12 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 11 results,  Open Access: 9 results) Presentation (16 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells2018

    • Author(s)
      Sonoda Soichiro、Mei Yu-feng、Atsuta Ikiru、Danjo Atsushi、Yamaza Haruyoshi、Hama Shion、Nishida Kento、Tang Ronghao、Kyumoto-Nakamura Yukari、Uehara Norihisa、Kukita Toshio、Nishimura Fusanori、Yamaza Takayoshi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 3419-3419

    • DOI

      10.1038/s41598-018-21183-6

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impaired neurite development associated with mitochondrial dysfunction in dopaminergic neurons differentiated from exfoliated deciduous tooth-derived pulp stem cells of children with autism spectrum disorder.2018

    • Author(s)
      Nguyen HTN, Kato H, Masuda K, Yamaza H, Hirofuji Y, Sato H, Phama T, Takayama F, Sakai Y,Ohga S, Taguchi T, Nonaka K
    • Journal Title

      Biochem Biophys Rep

      Volume: 16 Pages: 24-31

    • DOI

      10.1016/j.bbrep.2018.09.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pamidronate decreases bilirubin-impaired cell death and improves dentinogenic dysfunction of stem cells from human deciduous teeth.2018

    • Author(s)
      Yamaza H, Sonoda S, Nonaka K, Kukita T, Yamaza T.
    • Journal Title

      Stem Cell Res.Ther.

      Volume: 9 Issue: 1 Pages: 303-314

    • DOI

      10.1186/s13287-018-1042-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of AKT-mTOR signal pathway enhances osteogenic/dentinogenic capacity of stem cells from apical papilla2018

    • Author(s)
      Tanaka Yosuke、Sonoda Soichiro、Yamaza Haruyoshi、Murata Sara、Nishida Kento、Hama Shion、Kyumoto-Nakamura Yukari、Uehara Norihisa、Nonaka Kazuaki、Kukita Toshio、Yamaza Takayoshi
    • Journal Title

      Stem Cell Research & Therapy

      Volume: 9 Issue: 1 Pages: 334-334

    • DOI

      10.1186/s13287-018-1077-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altered development of dopaminergic neurons differentiated from stem cells from human exfoliated deciduous teeth of a patient with Down syndrome2018

    • Author(s)
      Pham Thanh Thi Mai、Kato Hiroki、Yamaza Haruyoshi、Masuda Keiji、Hirofuji Yuta、Sato Hiroshi、Nguyen Huong Thi Nguyen、Han Xu、Zhang Yu、Taguchi Tomoaki、Nonaka Kazuaki
    • Journal Title

      BMC Neurology

      Volume: 18 Issue: 1 Pages: 132-132

    • DOI

      10.1186/s12883-018-1140-2

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Mitochondrial dysfunction in dopaminergic neurons differentiated from exfoliated deciduous tooth-derived pulp stem cells of a child with Rett syndrome2018

    • Author(s)
      Hirofuji Saki、Hirofuji Yuta、Kato Hiroki、Masuda Keiji、Yamaza Haruyoshi、Sato Hiroshi、Takayama Fumiko、Torio Michiko、Sakai Yasunari、Ohga Shouichi、Taguchi Tomoaki、Nonaka Kazuaki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 498 Issue: 4 Pages: 898-904

    • DOI

      10.1016/j.bbrc.2018.03.077

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bilirubin reversibly affects cell death and odontogenic capacity in stem cells from human exfoliated deciduous teeth2018

    • Author(s)
      Yamaza H、Tomoda E、Sonoda S、Nonaka K、Kukita T、Yamaza T
    • Journal Title

      Oral Diseases

      Volume: 00 Issue: 5 Pages: 1-11

    • DOI

      10.1111/odi.12827

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accelerated dentinogenesis by inhibiting the mitochondrial fission factor, dynamin related protein 12018

    • Author(s)
      Matsuishi Yumiko I.、Kato Hiroki、Masuda Keiji、Yamaza Haruyoshi、Hirofuji Yuta、Sato Hiroshi、Wada Hiroko、Kiyoshima Tamotsu、Nonaka Kazuaki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 495 Issue: 2 Pages: 1655-1660

    • DOI

      10.1016/j.bbrc.2017.12.026

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Direct effects of mitochondrial dysfunction on poor bone health in Leigh syndrome2017

    • Author(s)
      Kato Hiroki、Han Xu、Yamaza Haruyoshi、Masuda Keiji、Hirofuji Yuta、Sato Hiroshi、Pham Thanh Thi Mai、Taguchi Tomoaki、Nonaka Kazuaki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 493 Issue: 1 Pages: 207-212

    • DOI

      10.1016/j.bbrc.2017.09.045

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondria Regulate the Differentiation of Stem Cells from Human Exfoliated Deciduous Teeth2017

    • Author(s)
      Kato H, Thi Mai Pham T, Yamaza H, Masuda K, Hirofuji Y, Han X, Sato H, Taguchi T, Nonaka K
    • Journal Title

      Cell Structure and Function

      Volume: 42 Issue: 2 Pages: 105-116

    • DOI

      10.1247/csf.17012

    • NAID

      130005982848

    • ISSN
      0386-7196, 1347-3700
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Engineering of Systematic Elimination of a Targeted Chromosome in Human Cells.2017

    • Author(s)
      Sato H, Kato H, Yamaza H, Masuda K, Nguyen HT, Pham TT, Han X, Hirofuji Y, Nonaka K
    • Journal Title

      Biomed Res Int

      Volume: - Pages: 1-5

    • DOI

      10.1155/2017/6037159

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dihydroorotate dehydrogenase depletion hampers mitochondrial function and osteogenic differentiation in osteoblasts.2016

    • Author(s)
      Fang J, Yamaza H, Uchiumi T, Hoshino Y, Masuda K, Hirofuji Y, Wagener FA, Kang D, Nonaka K
    • Journal Title

      Eur J Oral Sci

      Volume: 124 Issue: 3 Pages: 241-245

    • DOI

      10.1111/eos.12270

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Bilirubin reversibly affects cell death and odontogenic capacity of SHED2018

    • Author(s)
      Haruyoshi Yamaza
    • Organizer
      ASCB|EMBO 2018 meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 歯の早期脱落から低ホスファターゼ症の診断に至った1例2018

    • Author(s)
      高山扶美子 ,山座治義, 小笠原貴子, 野中和明
    • Organizer
      第36回日本小児歯科学会九州地方会および総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 造血幹細胞移植前のFanconi貧血の患児に対する歯科的アプローチに関する1例2018

    • Author(s)
      廣藤早紀、高山扶美子, 山座治義, 野中和明
    • Organizer
      第36回日本小児歯科学会九州地方会および総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 乳歯歯髄由来幹細胞におけるビリルビンの可逆的影響2018

    • Author(s)
      山座治義, 野中和明
    • Organizer
      第56回日本小児歯科学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ヒト脱落乳歯由来幹細胞を活性化したミトコンドリア病の病態解明2018

    • Author(s)
      韓旭, 加藤大樹, 山座治義, 増田啓次, 廣藤雄太, 野中和明
    • Organizer
      第56回日本小児歯科学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 下顎左側乳臼歯部歯牙腫と上顎左側乳臼歯部歯根嚢胞を併発した1例2018

    • Author(s)
      髙山扶美子, 増田啓次, 山座治義, 小笠原貴子, 廣藤雄太, 廣藤早紀, 野中和明
    • Organizer
      第56回日本小児歯科学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 9歳臼歯についての検討2017

    • Author(s)
      木舩敏郎、小笠原貴子、山座治義、野中和明
    • Organizer
      第35回日本小児歯科学会九州地方会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 松石裕美子、小笠原貴子、山座治義、増田啓次、野中和明2017

    • Author(s)
      上顎右側乳中切歯部に発生したエナメル上皮線維象牙質腫の1例
    • Organizer
      第55回日本小児歯科学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 木舩敏郎、増田啓次、山座治義、廣藤雄太、野中和明2017

    • Author(s)
      トモシンセシスを使った上顎の即時混合歯列分析
    • Organizer
      第55回日本小児歯科学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Thanh Thi Mai Pham, Haruyoshi Yamaza, Keiji Masuda, Yuta Hirofuji, Kazuaki Nonaka2017

    • Author(s)
      Impairment of Dopaminergic Neuronal Development in Down Syndrome.
    • Organizer
      第55回日本小児歯科学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Prediction of Maxillary Canine and Premolar Width using Tomosynthesis Paoramic Radiograph2016

    • Author(s)
      Kifune T, Masuda K, Yamaza H, Nnaka K
    • Organizer
      10th Biennial Conference of the Pediatric Dentistry Association of Asia in conjunction with 54th Annual Conference of the Japanese Society of Pediatric Dentistry
    • Place of Presentation
      Tokyo
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The Role of Mitochondria RNA Protein in Drosophila Melanogaster2016

    • Author(s)
      Hirofuji Y, Nonaka K, Yamaza H
    • Organizer
      10th Biennial Conference of the Pediatric Dentistry Association of Asia in conjunction with 54th Annual Conference of the Japanese Society of Pediatric Dentistry
    • Place of Presentation
      Tokyo
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 萌出遅延により埋伏した下顎左側第一大臼歯の象牙質に侵攻したエックス線透過性病変を認めた1例2016

    • Author(s)
      小笠原貴子、増田啓次、山座治義、野中和明
    • Organizer
      第34回日本小児歯科学会九州地方会
    • Place of Presentation
      宮崎
    • Related Report
      2016 Research-status Report
  • [Presentation] 腫瘍崩壊症候群を合併した急性骨髄性白血病の患児に全身麻酔下歯科治療を行った1例2016

    • Author(s)
      林 花凛、小笠原貴子、山座治義、増田啓二、野中和明
    • Organizer
      第34回日本小児歯科学会九州地方会
    • Place of Presentation
      宮崎
    • Related Report
      2016 Research-status Report
  • [Presentation] ヒト乳歯幹細胞におけるビリルビン添加による細胞生存への影響2016

    • Author(s)
      友田恵利佳、山座孝義、山座治義、田中陽介、園田聡一朗、野中和明、久木田敏夫
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌
    • Related Report
      2016 Research-status Report
  • [Presentation] 口唇口蓋裂患児由来乳歯幹細胞の解析2016

    • Author(s)
      山座孝義、山座治義、園田聡一朗、友田恵利佳、田中陽介、上原範久、久本由香里、野中和明、久木田敏夫
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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