• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of the genetic factor for mesiodens formation

Research Project

Project/Area Number 16K11813
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthodontics/Pediatric dentistry
Research InstitutionNihon University

Principal Investigator

SHIMIZU Takehiko  日本大学, 松戸歯学部, 教授 (40328761)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords正中過剰歯 / 遺伝要因 / 一塩基多型 / SNP / 上顎正中過剰歯 / 家族性 / ゲノム
Outline of Final Research Achievements

A mesiodens is the most common supernumerary tooth present in the maxillary incisor area. This study aimed to identify genes associated with susceptibility to mesiodens formation. Single nucleotide polymorphisms (SNPs) genotyping array analysis revealed that suggestive differences between mesiodens group and controls in allele frequencies of SNPs on chromosome 19, X and 2.
Allele frequencies of 5 SNPs in genes associated with supernumerary incisor formation in rodents were compared between the two groups. In addition, SNPs in 16 genes associated with the initiation of odontogenesis were tested. No positive polymorphisms were found in the tested SNPs between the two groups. These results suggest that these SNPs might not be candidates of genetic marker for mesiodens formation.

Academic Significance and Societal Importance of the Research Achievements

上顎正中過剰歯は、永久前歯の位置異常や発育障害の原因となるため、治療の原則は過剰歯の早期診断と抜去である。本研究の成果は、 上顎正中過剰歯発症の早期診断を行うために、遺伝子マーカーを用いた遺伝子検査確立のための新たな方略、方向性を示すものであり、今後の歯科臨床の発展に大きく寄与するものと考えられる。本研究の成果は、今後19、X、2番染色体上の遺伝子のさらなる調査の可能性を示したとともに、上顎正中過剰歯発症に関与する歯の初期発生関連遺伝子の多型マーカーは、高頻度の一塩基多型の箇所ではなく、より稀な頻度で現れる他の多型の可能性を示した。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2018 2017 2016

All Journal Article (1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] 歯科疾患の発症リスクを遺伝から考える2018

    • Author(s)
      清水武彦
    • Journal Title

      歯界展望

      Volume: 132 Pages: 5-8

    • Related Report
      2018 Annual Research Report
  • [Presentation] Genetic Mapping of Supernumerary Teeth in the Maxillary Incisor Area2017

    • Author(s)
      Nao Kimura, Chihiro Watanabe, Takehiko Shimizu.
    • Organizer
      International association for dental research (IADR)
    • Place of Presentation
      サンフランシスコ, アメリカ合衆国
    • Year and Date
      2017-03-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 口腔疾患の発症リスクを遺伝から考える2017

    • Author(s)
      清水武彦
    • Organizer
      日本小児歯科学会関東地方会第32回大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 上顎正中過剰歯発症に関わる遺伝学的研究2016

    • Author(s)
      木村奈緒、渡邉千尋、清水武彦
    • Organizer
      第54回日本小児歯科学会
    • Place of Presentation
      東京ドームホテル(東京都文京区)
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi