Clarification of biological effects of lasers/LEDs and development of novel comprehensive periodontal pocket therapy
| Project/Area Number |
16K11825
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Aoki Akira 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30302889)
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| Co-Investigator(Kenkyū-buntansha) |
竹内 康雄 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (60396968)
水谷 幸嗣 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (60451910)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 歯周炎 / 光 / レーザー / LED / 歯周ポケット / 骨切削 / 殺菌 / インプラント周囲炎 / 細胞増殖 |
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| Outline of Final Research Achievements |
In the present study, in order to clarify biological effects of Er:YAG laser in the treatment and prevention of periodontitis and peri-implantitis, various effects of this laser on gingival fibroblasts, osteoblasts, and bone tissue were investigated, and favorable positive effects regarding promotion of wound healing were demonstrated. Also, a novel comprehensive periodontal pocket treatment protocol using an Er:YAG laser was developed, effects of LEDs on cells/bacteria were clarified, and application of OCT in the treatment of periodontal disease were considered. Thus, various basic and clinical researches were conducted.
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| Academic Significance and Societal Importance of the Research Achievements |
歯周治療においては，従来，機械的治療が主に用いられているなかで，近年レーザーやLEDをはじめとする光エネルギーの応用が徐々に増加しつつある．とくに歯周治療においては，Er:YAGレーザーの応用の有効性が多数報告されている．本研究により，Er:YAGレーザーの生物学的効果が新規に多数明らかにされ，学術的意義が高いエビデンスが得られた．新しく開発された歯周ポケット治療法とともに，レーザーの臨床応用の発展のために大きな意義があると考えられる．今後の歯周・インプラント周囲光治療に大きな影響を有する優れた成果が得られたと考えられる．
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Report
(5 results)
Research Products
(149 results)
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[Journal Article] 東京医科歯科大学歯学部歯学科学生の歯周治療臨床実習の改革とその現状 - 2018年卒業生の実習内容とその実績から -2020
Author(s)
青木 章, 竹内康雄, 秋月達也, 水谷幸嗣, 片桐さやか, 池田裕一, 前川祥吾, 渡辺数基, 海老原新, 秀島雅之, 二階堂徹, 小田 茂, 荒木孝二, 岩田隆紀, 和泉雄一
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Journal Title
日歯周誌
Volume: 62
Pages: 38-46
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] Comprehensive analysis of gene expression related to healing after bone ablation with Er:YAG laser2019
Author(s)
Ohsugi Y, Aoki A, Mizutani K, Katagiri S, Komaki M, Noda M, Takagi T, Kakizaki S, Kitanaka Y, Lin T, Meinzer W, Izumi Y
Organizer
Academy of Laser Dentistry (ALD) 2019
Related Report
Int'l Joint Research
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[Presentation] レーザー装置によって異なる歯肉蒸散のex vivo評価2019
Author(s)
川村梨恵, 水谷幸嗣, 林 泰誠, 柿崎 翔, 三又絢子, 渡邊 剛, 斎藤徳人, Meinzer Walter, 和泉雄一, 岩田隆紀, 青木 章
Organizer
第62回春季歯周病学会学術大会
Related Report
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[Presentation] Comprehensive gene expression analysis in rat calvarial bone after ablation with Er:YAG laser and the effects of Er:YAG laser on osteocytes2019
Author(s)
Osugi Y, Katagiri S, Mizutani K, Takagi T, Kakizaki S, Kitanaka Y, Watanabe K, Niimi H, Meinzer W, Hirota T, Iwata T, Aoki A
Organizer
The 105th Annual meeting American Academy of Periodontology
Related Report
Int'l Joint Research
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[Presentation] Microarray analysis of comprehensive gene expression in rat calvarial bone after Er:YAG laser ablation2019
Author(s)
Ohsugi Y, Katagiri S, Mizutani K, Takagi T, Kakizaki S, Kitanaka Y, Watanabe K, Niimi H, Hatasa M, Shimohira T, Meinzer W, Hirota T, Iwata T, Aoki A
Organizer
The first asian pacific division of the World Federation for Laser Dentistry
Related Report
Int'l Joint Research
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[Presentation] A new screening system for periodontitis using Hepatocyte growth factor2018
Author(s)
Maekawa S, Suzuki S, Aoki A, Katagiri S, Ikeda Y, Ejiri K, Kong S, Nagata M, Yamaguchi Y, Ohshima M, Izumi Y
Organizer
The 104th Annual Meeting of American Academy of Periodontology
Related Report
Int'l Joint Research
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[Presentation] 東京医科歯科大学歯学部第5・第6学年の歯周治療臨床実習の現状2018
Author(s)
青木 章, 竹内康雄, 秋月達也, 水谷幸嗣, 片桐さやか, 池田裕一, 前川祥吾, 渡辺数基, 松浦孝典, 大津杏理, 柿﨑 翔, 駒崎利奈, 三上理沙子, 秀島雅之, 二階堂 徹, 荒木孝二, 和泉雄一
Organizer
第61回春季日本歯周病学会学術大会
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[Presentation] Dental hard tissue ablation using a newly-developed tunable nanosecond pulsed Cr:CdSe laser at a wavelength range of 2.76-3.00 um2016
Author(s)
Lin T, Aoki A, Saito N, Yumoto M, Nakajima S, Nagasaka K, Ichinose S, Mizutani K, Wada S, Izumi Y
Organizer
15th Congress of the World Federation for Laser Dentistry
Place of Presentation
Aichi Industry Labor & Center (WINC Aichi) (Nagoya, Japan)
Year and Date
2016-07-17
Related Report
Int'l Joint Research
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