| Project/Area Number |
16K12608
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental impact assessment
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| Research Institution | Chiba University |
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Principal Investigator |
Mori Chisato 千葉大学, 大学院医学研究院, 教授 (90174375)
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| Co-Investigator(Kenkyū-buntansha) |
江口 哲史 千葉大学, 予防医学センター, 助教 (70595826)
櫻井 健一 千葉大学, 予防医学センター, 准教授 (80323434)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | DNAメチル化 / 臍帯動脈 / 環境化学物質 / 子宮内環境 / 胎児期環境因子 / 動脈硬化症 / DOHaD研究 / 胎児環境因子 / 環境影響評価 / 化学物質 / 血管 / 次世代環境影響評価 |
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| Outline of Final Research Achievements |
The purpose of this study was to clarify the effect of the fetal environment on the epigenetic status of blood vessels. In a birth cohort study, umbilical arteries were obtained at birth and Their DNA was extracted. To examine the relationship between DNA methylation and prenatal environmental factors, we assessed correlations between one of the persistent organic pollutants, PCB, or birth weight and DNA methylation levels. No correlation was found between serum PCB concentrations and DNA methylation levels of umbilical arteries, but there was a site showing a correlation with the birth weight. To clarify the effects of the methylation status in the umbilical artery, we attempted to regulate DNA methylation, but failed to show sufficient changes.
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| Academic Significance and Societal Importance of the Research Achievements |
胎児期の栄養環境が成人後の心血管疾患に影響を与えることが報告されている（DOHaD学説）。本研究では胎児期環境因子が血管のエピジェネティクスに与える影響の一端を示すことができた。DNAメチル化は長期間保存されることが示されており、この変化の生物学的意義やメチル化状態を変化させる手法を開発することができれば、心血管疾患の先制医療の確立に貢献するものと考える。
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