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The best dietary schedule for cancer prevention in Japanese food with reflecting the bioavailability

Research Project

Project/Area Number 16K12708
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionKyoto Prefectural University

Principal Investigator

Nakamura Yasushi  京都府立大学, 和食文化研究センター, 教授 (90285247)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords大根 / がん予防 / 生体内利用能 / 非侵襲的試験 / 尿中マーカー / MTBITC / 摂取時期 / 季節変動 / 和食文化 / 辛み成分 / がん / ダイコン / 和食 / 京野菜 / イソチオシアン酸
Outline of Final Research Achievements

MTBITC (cancer preventive isothiocyanate in daikon: 4-methylthio-3-butenyl isothiocyanate) bioavailability varied among human volunteers, and the MTBITC cancer preventive effect therefore depends on the individual even in the same MTBITC administration level. The difference depends on generations and season in individual intake, and the variation factor of the MTBITC bioavailability should be generation and season. The best dietary schedule for cancer prevention in Japanese food with reflecting the bioavailability might be determined the MTBITC-bioavailability test.

Academic Significance and Societal Importance of the Research Achievements

和食の中に世界で日本人のみがもつ食材や食習慣があれば,そこに日本人の長寿要因があるはずであるという概念のもと,世界で日本人のみがもつ「大根おろしを食べる」という食習慣に注目して,大根がもつ長寿要因の科学的解明を試みた.大根特有の辛み成分は発がん抑制成分でもあるが,いつ,どのように,どれだけの大根を摂取したら期待する発がん抑制効果が得られるのかを,生体内利用能測定試験を開発して明らかにした.大根の発がん抑制作用は,個人により最大に得られる季節が異なることがわかり,これを念頭において大根を用いた料理を楽しむことが発がん抑制による健康長寿に有効であると考えられた.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (2 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Funded Workshop (1 results)

  • [Int'l Joint Research] King Mongkut's University of Technology/Mahidol University(Thailand)

    • Related Report
      2017 Research-status Report
  • [Journal Article] 4-Methylthio-3-butenyl isothiocyanate (MTBITC) induced apoptotic cell death and G2/M cell cycle arrest via ROS production in human esophageal epithelial cancer cells2019

    • Author(s)
      Hirata Tadashi、Cho Young-Man、Suzuki Isamu、Toyoda Takeshi、Akagi Jun-ichi、Nakamura Yasushi、Numazawa Satoshi、Ogawa Kumiko
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 44 Issue: 2 Pages: 73-81

    • DOI

      10.2131/jts.44.73

    • NAID

      130007590638

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 4-Methylthio-3-butenyl isothiocyanate mediates nuclear factor (erythroid-derived 2)-like 2 activation by regulating reactive oxygen species production in human esophageal epithelial cells.2018

    • Author(s)
      Hirata T, Cho YM, Suzuki I, Toyoda T, Akagi JI, Nakamura Y, Numazawa S, Ogawa K.
    • Journal Title

      Food Chem Toxicol

      Volume: 111 Pages: 295-301

    • DOI

      10.1016/j.fct.2017.11.022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protection of Kyo-yasai (heirloom vegetables in Kyoto) from extinction: a case of Sabaka-daikon (Japan's heirloom white radish, Raphanus sativus ) in Maizuru, Japan2017

    • Author(s)
      Nakamura Takako、Nakamura Yasushi、Sasaki Azusa、Fujii Masami、Shirota Koji、Mimura Yutaka、Okamoto Shigehisa
    • Journal Title

      J. Ethn. Foods

      Volume: 4 Issue: 2 Pages: 103-109

    • DOI

      10.1016/j.jef.2017.05.008

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Protection of Kyo-yasai (Heirloom Vegetables in Kyoto) in Washoku (Japanese Cuisine) Materials from Extinction: A Case of Sabaka-daikon2017

    • Author(s)
      Yasushi Nakamura
    • Organizer
      Basic and Applied Studies of Ethnic Food Materials for Human Health
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Ethnic food materials for human health in Japan and Southeast Asia based on Washoku (Japanese cuisine) study2016

    • Author(s)
      Yasushi Nakamura
    • Organizer
      Basic and Applied Studies of Ethnic Food Materials for Human Health
    • Place of Presentation
      University Hall 2F, Kyoto Prefectural University (Japan)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Funded Workshop] Basic and Applied Studies of Ethnic Food Materials for Human Health2017

    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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