Search for markers for the prevention and treatment of Alzheimer's disease by polyphenols that can diagnose with one drop of blood
| Project/Area Number |
16K12718
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kobayashi Shoko 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (90348144)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アルツハイマー病 / バイオマーカー / ロスマリン酸 / ポリフェノール / 脳機能 / 脳神経疾患 / 痴呆 |
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| Outline of Final Research Achievements |
A study of rosmarinic acid (RA) that highly inhibit the aggregation of amyloid β(Aβ)both in vitro and in vivo. In this study, after feeding RA to AD model mice (RA group), cognitive function and aggregation of Aβ was checked, and therapeutic reactive bio-markers in their blood. RA group had more suppression, decreasing cognitive function was more than the control group. Some compound of RA group showed an inverse correlation with C group by comprehensive analysis. These compounds might be therapeutic reactive bio-markers of AD.
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| Academic Significance and Societal Importance of the Research Achievements |
アルツハイマー病（AD）は、症状が現れる約20年前から脳内Aβ蓄積などの脳内変化が始まっていること、また認知症の病態が進行してしまうと、治療が困難であることから、発症前や初期段階での診断、および予防・治療が重要かつ効果的である。本研究では侵襲性の低い血漿中から、ロスマリン酸摂食によるAD予防効果に伴い変動する、AD発症遅延反応性マーカー候補を見出した。
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Report
(3 results)
Research Products
(5 results)
