| Project/Area Number |
16K12724
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 加齢 / ストレス / 子宮 / 卵巣 / 酸化ストレス / 妊娠期 / 授乳期 / ミルク / 老化 / 3-ニトロプロピオン酸 / 活性酸素 / 脳 / アミノ酸 / 女性 / 生殖器官 / 卵子 / 栄養 |
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| Outline of Final Research Achievements |
Many free amino acids were found to be significantly higher in the uterus and ovary of middle age mice than in those of young age mice. There was no effect of stress on the free amino acid concentration of uterus and ovary. In addition, compared to the young age, reactive oxygen species increased in the oocytes of middle age mice, but no deterioration in egg quality was confirmed.
Significant decreases were observed in some free amino acids of maternal plasma in the stress-loaded group during pregnancy. On the other hand, there was no change in free amino acid concentration in milk. It was revealed that the stress burden during lactation significantly lowered plasma many free amino acids in mother mice. In addition, changes in the free amino acid concentration of milk were observed by receiving stress directly during lactation.
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