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Prevention of catechin oligomer on sarcopenia via sympathethic nerve

Research Project

Project/Area Number 16K12731
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionShibaura Institute of Technology

Principal Investigator

Osakabe Naomi  芝浦工業大学, システム理工学部, 教授 (30554852)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsカテキンオリゴマー / 交感神経 / サルコペニア / 筋委縮 / ロコモーティブシンドローム / 筋萎縮 / 廃用性 / テアフラビン / ユビキチンリガーゼ / 機能性食品
Outline of Final Research Achievements

In the present study, we examined the effect of flavan 3-ols(FL) on disuse muscle atrophy induced by hindlimb suspension in mice. Male C57BL/6J mice were assigned to four groups as follows: unsuspended-vehicle, unsuspended- FL, suspended-vehicle, and suspended-FL. Mice in the vehicle treatment groups were administered distilled water and those in the FL treatment groups were dosed with FL (50mg/kg/day) for 2weeks. The weights of the gastrocnemius (GC), tibialis anterior (TA), and soleus (SOL), but not the extensor digitorum longus (EDL), decreased significantly in mice with hindlimb suspension (-11.8%, -16.5%, and -41.0%, respectively). This reduction in GC, TA, and SOL mass was inhibited by FL (-5.3%, +2.0%, and -16.6%, respectively). The FL increased the EDL weight >20% with or without hindlimb suspension. These results suggested that FL delayed disuse muscle atrophy by metabolic alteration.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice2017

    • Author(s)
      Ito Mao、Kudo Naoto、Miyake Yuji、Imai Tatsuya、Unno Tomoki、Yamashita Yoko、Hirota Yoshihisa、Ashida Hitoshi、Osakabe Naomi
    • Journal Title

      Experimental Gerontology

      Volume: 98 Pages: 120-123

    • DOI

      10.1016/j.exger.2017.07.010

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Flavan 3-ols retarded muscle atrophy induced by hindlimb suspention in mice2017

    • Author(s)
      Ito M. Osakabe N.
    • Organizer
      10th SEATUC Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Metabolic alteration of skeletal muscle induced by the administration of anthocyanidins or procyanidins in mice2017

    • Author(s)
      Ito M, Imai T, Kudo N, Miyake Y, Nakamura M, Kato Y, Osawa T, Osakabe N.
    • Organizer
      9th International Workshop on Anthocyanin
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2019-03-29  

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