Novel mechanism how hypothalamus senses the lipid of the blood.
| Project/Area Number |
16K12735
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Tohoku University |
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Principal Investigator |
Owda Yuji 東北大学, 医学系研究科, 教授 (20292211)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | マウス / 視床下部 / 弓状核 / グリア細胞 / 脂質 / レプチン / 高脂肪食 / アストロサイト / オリゴデンドロサイト |
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| Outline of Final Research Achievements |
The hypothalamus is involved in the regulation of food intake and energy homeostasis. However, the molecular mechanisms involved in these activities remain largely unknown. In this study, we examined in detail the localization of fatty acid-binding protein 7 (FABP7) in the hypothalamic ARC. Immunohistochemistry revealed that FABP7+ cells are NG2+ or GFAP+ in the ARC. In mice fed a high-fat diet, weight gain and food intake were lower in FABP7 KO mice than in wild-type (WT) mice. FABP7 KO mice also had lower food intake and weight gain after a single injection of leptin, and we consistently confirmed that the number of pSTAT3+ cells in the ARC indicated that the leptin-induced activation of neurons was significantly more frequent in FABP7 KO mice than in WT mice.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7.2017
Author(s)
Gerstner JR, Perron IJ, Riedy SM, Yoshikawa T, Kadotani H, Owada, Y, Van Dongen HPA, Galante RJ, Dickinson K, Yin JCP, Pack AI, Frank MG.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Microglia-derived neuregulin expression in psychiatric disorders.2017
Author(s)
Ikawa D, Makinodan M, Iwata K, Ohgidani M, Kato TA, Yamashita Y, Yamamuro K, Kimoto S, Toritsuka M, Yamauchi T, Fukami SI, Yoshino H, Okumura K, Tanaka T, Wanaka A, Owada Y, Tsujii M, Sugiyama T, Tsuchiya K, Mori N, Hashimoto R, Matsuzaki H, Kanba S, Kishimoto T.
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Journal Title
Brain Behav Immun.
Volume: 61
Pages: 375-385
DOI
Related Report
Peer Reviewed / Open Access
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