Does lactate facilitate regeneration of injured skeletal muscle?
| Project/Area Number |
16K12942
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Toyohashi Sozo University |
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Principal Investigator |
OHNO Yoshitaka 豊橋創造大学, 保健医療学部, 講師 (80440808)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 骨格筋 / 細胞・組織 / リハビリテーション |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the effects of lactate on the regeneration of injured skeletal muscle. Cardiotoxin (CTX) was injected into mouse tibialis anterior (TA) muscle. Oral administration of sodium lactate increased the muscle weight and number of Pax7-positive nuclei in CTX-injected TA muscle. Mouse myoblast C2C12 cells were differentiated to form myotubes. Lactate was administered to the differentiation medium. Lactate administration increased the diameter of C2C12 myotubes in a dose-dependent manner. Lactate administration also increased myonuclei number and upregulated the p42/44 extracellular signal-regulated kinase-1/2 (Erk1/2) signaling. These observations suggest that lactate may have a positive effect on the regeneration of injured skeletal muscle.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Suppression of myostatin stimulates regenerative potential of injured antigravitational soleus muscle in mice under unloading condition2016
Author(s)
Ohno, Y., Matsuba, Y., Hashimoto, N., Sugiura, T., Ohira, Y., Yoshioka, T., Goto, K.
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Journal Title
International Journal of Medical Sciences
Volume: 13
Issue: 9
Pages: 680-685
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Heat shock transcription factor 1-associated expression of slow myosin heavy chain in mouse soleus muscle in response to unloading with or without reloading2016
Author(s)
Yokoyama S, Ohno Y, Egawa T, Yasuhara K, Nakai A, Sugiura T, Ohira Y, Yoshioka T, Okita M, Origuchi T, Goto K
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Journal Title
Acta Physiol (Oxf)
Volume: 217
Issue: 4
Pages: 325-337
DOI
Related Report
Peer Reviewed / Open Access
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