| Project/Area Number |
16K13049
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Hokkaido Pharmaceutical University School of Pharmacy |
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Principal Investigator |
Chono Sumio 北海道薬科大学, 薬学部, 教授 (90347790)
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| Co-Investigator(Renkei-kenkyūsha) |
TOGAMI KOHEI 北海道科学大学, 薬学部, 准教授 (20582357)
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| Research Collaborator |
ZHAN XIUYAN
KANEHIRA YUKIMUNE
ISHIZAWA KIYOMI
HACHISU REI
INOUE SHINYA
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | イメージング / 動脈プラーク / 検査 / 抗体修飾リポソーム / DDS / 検査・治療 |
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| Outline of Final Research Achievements |
The liposomes modified with specific antibody for macrophages and foam cells was prepared, and their efficacy as drug delivery system for detection and therapy of artery plaque was evaluated. Antibody-modified liposomes efficiently delivered drugs to macrophages and foam cells, compared with non-modified liposomes. This study suggests that antibody-modified liposomes are useful as drug delivery system for detection of artery plaque.
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