Research on salt appetite and emotion
| Project/Area Number |
16K13108
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic / Social brain science
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
HIYAMA Takeshi 基礎生物学研究所, 統合神経生物学研究部門, 助教 (90360338)
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| Project Period (FY) |
2016-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | Naセンサー / 体液恒常性 / グリア細胞 / 神経回路 / 体液 / イオンチャネル / グリア / ニューロン / 脳室周囲器官 / 分界条床核 / 神経科学 / 脳・神経 / 生理学 / ストレス |
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| Outline of Final Research Achievements |
In the subfornical organ (SFO), we here found distinct groups of excitatory neurons driving thirst and salt appetite, respectively. We refer to them as ‘water neurons’ and ‘salt neurons’, respectively. Salt neurons innervated the ventral part of the bed nucleus of the stria terminalis (vBNST). BNST is a center of integration for limbic information and valence monitoring, and is important in psychiatric disease such as: the stress response, extended duration fear states and social behavior. We found that signals of Nax channels, sensing [Na+] in body fluids, controlled the activity of salt neurons through a group of GABAergic neurons; the GABAergic neurons were activated by lactate from glial cells expressing Nax channel. The natriorexigenic effects of Ang II thus appeared to be controlled based on the [Na+] in body fluids through the brain Na+-level sensor Nax.
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Report
(2 results)
Research Products
(14 results)
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[Journal Article] Adipsic Hypernatremia without Hypothalamic Lesions Accompanied by Autoantibodies to Subfornical Organ.2017
Author(s)
Hiyama TY, Utsunomiya AN, Matsumoto M, Fujikawa A, Lin CH, Hara K, Kagawa R, Okada S, Kobayashi M, Mayumi I, Anzo M, Cho H, Takayasu S, Nigawara T, Daimon M, Sato T, Terui K, Ito E, Noda M.
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Journal Title
Brain Pathol.
Volume: 27
Issue: 3
Pages: 323-331
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 体液調節機構のメカニズム2016
Author(s)
檜山武史
Organizer
天然薬物研究方法論アカデミー第19回シンポジウム
Place of Presentation
岡崎コンファレンスセンター（愛知県岡崎市）
Year and Date
2016-10-14
Related Report
Invited
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