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Research on salt appetite and emotion

Research Project

Project/Area Number 16K13108
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Basic / Social brain science
Research InstitutionNational Institute for Basic Biology

Principal Investigator

HIYAMA Takeshi  基礎生物学研究所, 統合神経生物学研究部門, 助教 (90360338)

Project Period (FY) 2016-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
KeywordsNaセンサー / 体液恒常性 / グリア細胞 / 神経回路 / 体液 / イオンチャネル / グリア / ニューロン / 脳室周囲器官 / 分界条床核 / 神経科学 / 脳・神経 / 生理学 / ストレス
Outline of Final Research Achievements

In the subfornical organ (SFO), we here found distinct groups of excitatory neurons driving thirst and salt appetite, respectively. We refer to them as ‘water neurons’ and ‘salt neurons’, respectively. Salt neurons innervated the ventral part of the bed nucleus of the stria terminalis (vBNST). BNST is a center of integration for limbic information and valence monitoring, and is important in psychiatric disease such as: the stress response, extended duration fear states and social behavior. We found that signals of Nax channels, sensing [Na+] in body fluids, controlled the activity of salt neurons through a group of GABAergic neurons; the GABAergic neurons were activated by lactate from glial cells expressing Nax channel. The natriorexigenic effects of Ang II thus appeared to be controlled based on the [Na+] in body fluids through the brain Na+-level sensor Nax.

Report

(2 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (14 results)

All 2017 2016 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (6 results) (of which Invited: 4 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Adipsic Hypernatremia without Hypothalamic Lesions Accompanied by Autoantibodies to Subfornical Organ.2017

    • Author(s)
      Hiyama TY, Utsunomiya AN, Matsumoto M, Fujikawa A, Lin CH, Hara K, Kagawa R, Okada S, Kobayashi M, Mayumi I, Anzo M, Cho H, Takayasu S, Nigawara T, Daimon M, Sato T, Terui K, Ito E, Noda M.
    • Journal Title

      Brain Pathol.

      Volume: 27 Issue: 3 Pages: 323-331

    • DOI

      10.1111/bpa.12409

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ2017

    • Author(s)
      Matsuda T, Hiyama TY, Niimura F, Matsusaka T, Fukamizu A, Kobayashi K, Kobayashi K, Noda M
    • Journal Title

      Nat Neurosci

      Volume: 20 Issue: 2 Pages: 230-241

    • DOI

      10.1038/nn.4463

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nax signaling evoked by an increase in [Na+] in CSF induces water intake via EET-mediated TRPV4 activation.2016

    • Author(s)
      Sakuta Hiraki, Eri Nishihara, Takeshi Y. Hiyama, Chia-Hao Lin, and Masaharu Noda
    • Journal Title

      American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

      Volume: 311 Issue: 2 Pages: R299-R306

    • DOI

      10.1152/ajpregu.00352.2015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of LacZ-Positive Cells in Living Tissue with Single-Cell Resolution.2016

    • Author(s)
      Doura T, Kamiya M, Obata F, Yamaguchi Y, Hiyama TY, Matsuda T, Fukamizu A, Noda M, Miura M, Urano Y
    • Journal Title

      Angew Chem Int Ed

      Volume: 55 Issue: 33 Pages: 9620-9624

    • DOI

      10.1002/anie.201603328

    • NAID

      40021583957

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sodium sensing in the subfornical organ and body-fluid homeostasis.2016

    • Author(s)
      Hiyama TY, Noda M
    • Journal Title

      Neurosci Res

      Volume: 113 Pages: 1-11

    • DOI

      10.1016/j.neures.2016.07.007

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 体液のNaモニタリングと水分・塩分欲求制御の脳内機構2017

    • Author(s)
      檜山武史
    • Organizer
      第12回環境生理プレコングレス
    • Place of Presentation
      サーラシティ浜松(静岡県浜松市)
    • Year and Date
      2017-03-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 塩の摂取量をコントロールすることは可能か: 口渇感と塩分欲求制御の脳内機構2017

    • Author(s)
      檜山武史
    • Organizer
      Hypertension Expert Seminar in Fukuoka
    • Place of Presentation
      グラナダスイート福岡「ザ・プラザ」(福岡県福岡市)
    • Year and Date
      2017-02-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 水分・塩分欲求制御の脳内機構とadipsic hypernatremia2017

    • Author(s)
      檜山武史
    • Organizer
      バゾプレシン研究会
    • Place of Presentation
      TKP 有楽町会議室(東京都中央区)
    • Year and Date
      2017-01-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 体液調節機構のメカニズム2016

    • Author(s)
      檜山武史
    • Organizer
      天然薬物研究方法論アカデミー第19回シンポジウム
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県岡崎市)
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 体液Naレベルの感知機構と生理機能2016

    • Author(s)
      檜山武史
    • Organizer
      第163回薬学談話会
    • Place of Presentation
      名古屋市立大薬学部(愛知県名古屋市)
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 感覚性脳室周囲器官を認識する自己抗体の産生と無飲症性高ナトリウム血症2016

    • Author(s)
      檜山武史 他 (22名中1番)
    • Organizer
      第89回日本内分泌学会学術総会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Book] 脳内環境辞典2017

    • Author(s)
      檜山武史 他
    • Total Pages
      156
    • Publisher
      メディカル ドゥ
    • Related Report
      2016 Annual Research Report
  • [Book] ブレインサイエンス・レビュー20172017

    • Author(s)
      檜山武史 他
    • Total Pages
      308
    • Publisher
      クバプロ
    • Related Report
      2016 Annual Research Report
  • [Remarks] 水ニューロンと塩ニューロンの発見 ~口渇感と塩分欲求が生じる脳機構の解明~

    • URL

      http://www.nibb.ac.jp/press/2016/12/20.html

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2018-03-22  

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