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The gut-brain axis examined by wireless optogenetics

Research Project

Project/Area Number 16K13110
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Basic / Social brain science
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Takumi Toru  国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (00222092)

Co-Investigator(Renkei-kenkyūsha) YAMANAKA Akihiro  名古屋大学, 環境医学研究所, 教授 (60323292)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords脳腸連関 / 腸内フローラ / 自閉症 / 光遺伝学 / オプトジェネテイクス
Outline of Final Research Achievements

The gut is called as the second brain and the gut-brain axis is an interesting network between organs for higher brain functions including cognitive function. To understand the higher brain function regulated by the autonomic nervous system, we develop the wire-less optogenetics to physiologically see the activity of the autonomic nervous system and the enteric nerves with relatively lower invasiveness. The results of this study will be a tool to examine the regulatory network between different organs.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2018 2017 2016

All Journal Article (10 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 10 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (8 results) (of which Int'l Joint Research: 3 results,  Invited: 6 results)

  • [Journal Article] The choroid plexus is an important circadian clock component2018

    • Author(s)
      Myung Jihwan、Schmal Christoph、Hong Sungho、Tsukizawa Yoshiaki、Rose Pia、Zhang Yong、Holtzman Michael J.、De Schutter Erik、Herzel Hanspeter、Bordyugov Grigory、Takumi Toru
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 1062-1062

    • DOI

      10.1038/s41467-018-03507-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Postsynaptic density proteins and their involvement in neurodevelopmental disorders.2018

    • Author(s)
      Takeshi Kaizuka, Toru Takumi
    • Journal Title

      The Journal of Biochemistry

      Volume: in press Issue: 6 Pages: 447-455

    • DOI

      10.1093/jb/mvy022

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CNV biology in neurodevelopmental disorders2018

    • Author(s)
      Takumi Toru、Tamada Kota
    • Journal Title

      Current Opinion in Neurobiology

      Volume: 48 Pages: 183-192

    • DOI

      10.1016/j.conb.2017.12.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of genes regulating GABAergic interneuron maturation.2018

    • Author(s)
      Fukumoto K, Tamada K, Toya T, Nishino T, Yanagawa Y, Takumi T
    • Journal Title

      Neurosci Res

      Volume: - Pages: 18-29

    • DOI

      10.1016/j.neures.2017.11.010

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Functional significance of rare neuroligin 1 variants found in autism2017

    • Author(s)
      Nakanishi Moe、Nomura Jun、Ji Xiao、Tamada Kota、Arai Takashi、Takahashi Eiki、Bu?an Maja、Takumi Toru
    • Journal Title

      PLOS Genetics

      Volume: 13 Issue: 8 Pages: e1006940-e1006940

    • DOI

      10.1371/journal.pgen.1006940

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Behavioral and neuroanatomical analyses in a genetic mouse model of 2q13 duplication2017

    • Author(s)
      Kishimoto Keiko、Nomura Jun、Ellegood Jacob、Fukumoto Keita、Lerch Jason P.、Moreno-De-Luca Daniel、Bourgeron Thomas、Tamada Kota、Takumi Toru
    • Journal Title

      Genes to Cells

      Volume: 22 Issue: 5 Pages: 436-451

    • DOI

      10.1111/gtc.12487

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Rodent models of genetic and chromosomal variations in psychiatric disorders.2017

    • Author(s)
      Nomura J, Kannan G, Takumi T
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 71 Issue: 8 Pages: 508-517

    • DOI

      10.1111/pcn.12524

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Distinct Defects in Spine Formation or Pruning in Two Gene Duplication Mouse Models of Autism.2017

    • Author(s)
      Wang M, Li H, Takumi T, Qiu Z, Xu X, Yu X, Bian WJ
    • Journal Title

      Neurosci Bull

      Volume: 33 Issue: 2 Pages: 143-152

    • DOI

      10.1007/s12264-017-0111-8

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Serotonin rebalances cortical tuning and behavior linked autism symptoms in 15q11-13 CNV mice.2017

    • Author(s)
      Nakai N, Nagano M, Saitow F, Watanabe Y, Kawamura Y, Kawamoto A, Tamada K, Mizuma H, Onoe H, Watanabe Y, Monai H, Hirase H, Nakatani J, Inagaki H, Kawada T, Miyazaki T, Watanabe M, Sato Y, Okabe S, Kitamura K, Kano M, Hashimoto K, Suzuki H, Takumi T
    • Journal Title

      Science Adv

      Volume: -

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CHD8 haploinsufficiency results in autistic-like phenotypes in mice2016

    • Author(s)
      Katayama, Y., Nishiyama, M., Shoji, H., Ohkawa, Y., Kawamura, A., Sato, T., Suyama, M., Takumi, T., Miyakawa, T., Nakayama, K. I.
    • Journal Title

      Nature

      Volume: 537 Issue: 7622 Pages: 675-679

    • DOI

      10.1038/nature19357

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Copy number variation models with autism2016

    • Author(s)
      Toru Takumi
    • Organizer
      14th Meeting of the Asian-Pacific Society for Neurochemistry
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2016-08-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Modeling autism2016

    • Author(s)
      Toru Takumi
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2016-07-22
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Calcium imaging of insular cortex during social interaction in freely moving mice2016

    • Author(s)
      Nobuo Kunori, Hiromi Monai, Youichi Iwai, Hajime Hirase, Toru Takumi
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2016-07-22
    • Related Report
      2016 Research-status Report
  • [Presentation] A virtual reality paradigm for testing social interaction in head-fixed mice2016

    • Author(s)
      Nobuhiro Nakai, Masaaki Sato, Yasunori Hayashi, Toru Takumi
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2016-07-22
    • Related Report
      2016 Research-status Report
  • [Presentation] 自閉スペクトラム症の生物学的理解2016

    • Author(s)
      内匠透
    • Organizer
      第46回日本神経精神薬理学会年会
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2016-07-02
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 発達障害の生物学的理解2016

    • Author(s)
      内匠透
    • Organizer
      第58回日本小児神経学会学術集会
    • Place of Presentation
      京王プラザホテル、東京
    • Year and Date
      2016-06-03
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Mouse model towards understanding the pathophysiology of autism2016

    • Author(s)
      Toru Takumi
    • Organizer
      KSBMB International Conference 2016
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2016-05-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular understanding of the pathophysiology of ASD2016

    • Author(s)
      Toru Takumi
    • Organizer
      ICNC 2016 Satellite Symposium
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-04-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2019-03-29  

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