Neural basis for contents and levels of consciousness in patients with disorders of consciousness.
| Project/Area Number |
16K13113
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic / Social brain science
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| Research Institution | National Rehabilitation Center for Persons with Disabilities |
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Principal Investigator |
Kansaku Kenji 国立障害者リハビリテーションセンター(研究所), 研究所 脳機能系障害研究部, 研究室長 (60399318)
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| Co-Investigator(Kenkyū-buntansha) |
高野 弘二 国立障害者リハビリテーションセンター(研究所), 研究所・脳機能系障害研究部, 研究員 (00510588)
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| Research Collaborator |
Okahara Yoji 国立障害者リハビリテーションセンター, 研究所 脳機能系障害研究部, 外来研究員
Utsumi Kota 国立障害者リハビリテーションセンター, 研究所 脳機能系障害研究部, 外来研究員
Kawase Toshihiro 国立障害者リハビリテーションセンター, 研究所 脳機能系障害研究部, 外来研究員
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | コミュニケーション / 意識内容 |
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| Outline of Final Research Achievements |
This study aimed to evaluate contents and levels of consciousness in patients with disorders of consciousness, and further to elucidate neural mechanisms of these patients.
To evaluate contents of consciousness, we applied language tasks (passive listening of stories) and recorded fMRI signals from unresponsive wakefulness syndrome (UWS) patients. We found that a few of the patients activated the posterior language areas, suggesting that these patients may comprehend speech. We also used brain-machine interface technologies, and found a patient who successfully operated the system. Further, in order to evaluate arousal levels of consciousness, we investigated physiological markers of relative change of subjective sleepiness by EEG measures. We found a strong correlation between the change of score calculated by the proposed method and the change of Karolinska Sleepiness Scale that assess subjective sleepiness.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Operation of a P300-based brain-computer interface in patients with Duchenne muscular dystrophy.2018
Author(s)
Utsumi, K., Takano, K., Okahara, Y., Komori, T., Onodera, O., Kansaku, K.
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Journal Title
Scientific Reports
Volume: 8
Issue: 1
Pages: 1753-1753
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Operation of a P300-based brain-computer interface by patients with spinocerebellar ataxia.2017
Author(s)
Okahara, Y., Takano, K., Komori, T., Nagao, M., Iwadate, Y., Kansaku, K.
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Journal Title
Clinical Neurophysiology Practice
Volume: 2
Pages: 147-153
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] P300-based brain-machine interface applied to patients with Duchenne muscular dystrophy.2017
Author(s)
Utsumi, K., Okahara, Y., Takano, K., Komori, T., Onodera, O., Kansaku, K.
Organizer
Real-time functional imaging and neurofeedback conference 2017.
Related Report
Int'l Joint Research
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[Presentation] Speech comprehension in patients with persistent vegetative state: a neuroimaging approach.2016
Author(s)
Okahara, Y., Utsumi, K., Takano, K., Odaka, K., Uchino, Y., Kansaku, K.
Organizer
The 46th Annual Meeting of the Society for Neuroscience
Place of Presentation
San Diego Convention Center, San Diego, USA
Related Report
Int'l Joint Research
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