| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
In this study, we aimed to develop new strategy by constructing DNA nanostructures which can penetrate the cell membrane and application to molecular delivery system. We designed and constructed a DNA origami structure having a needle-like portion that can penetrate the lipid membrane, and observed that it interacts with the lipid bilayer membrane and forms a lattice assembly by high-speed AFM. By using liposome which is a model system of the cell, the target molecule was successfully introduced into the liposome and biochemical reaction was initiated by penetrating the lipid membrane. Using this system, we develop a new system that can introduce the target molecule from the cell surface into the cell.
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