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Preparation of uni-axially swelling gels by multi-step cross-linking of macroscopically-oriented supergiant molecules

Research Project

Project/Area Number 16K14077
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Polymer/Textile materials
Research InstitutionJapan Advanced Institute of Science and Technology

Principal Investigator

Kaneko Tatsuo  北陸先端科学技術大学院大学, 先端科学技術研究科, 教授 (20292047)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsゲル / DDS / 架橋 / 多糖 / ラン藻 / 異方性 / 物質放出 / 液晶 / 物質輸送 / 分子配向 / XRD / 偏光顕微鏡観察 / 多糖類 / 配向 / 構造物性
Outline of Final Research Achievements

Anisotropic gels have direction dependence in various functions such as cell adhesion and substance transport/release, and are important in the development of new functional soft matters. In conducting researches on anisotropic gels, we have found that giant rigid molecules exhibit self-orientation at a very low concentrations and form milliscaled anisotropic domains. Therefore, based on these results, a molecularly-oriented gel was created by controlling the reactivity of chemical crosslinking, and a gel that swelled in only one direction like a coil spring was developed. Moreover, we discovered that the anisotropic releasability of substances such as a pigmen.

Academic Significance and Societal Importance of the Research Achievements

本研究では、コイルバネのように一方向のみに伸縮する究極の異方性ゲルが開発され、異方的編み目を作成するための架橋点形成に関する新規なケミストリーを展開できた。ここで得られる知見はゲル・ゴムなどの構成要素である高分子網目の新しい構造論の展開につながるため、高分子材料科学への貢献が強く期待される意義の高いものである。作成した異方的物質放出性ゲルシートを薬物送達剤システムとして活用すれば、非侵襲性医療として利用される経皮吸収システム開発において重要な知見を与える。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (35 results)

All 2019 2018 2017 2016

All Journal Article (11 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 11 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (23 results) (of which Int'l Joint Research: 8 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] Micro-deposition control of polysaccharides on evaporative air-LC interface to design quickly swelling hydrogels2019

    • Author(s)
      Gargi Joshi, Kosuke Okeyoshi, Tetsu Mitsumata, Tatsuo Kaneko
    • Journal Title

      Journal of Colloid and Interface Science

      Volume: 546 Pages: 184-191

    • DOI

      10.1016/j.jcis.2019.03.062

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Micro-patterned cell orientation of cyanobacterial liquid-crystalline hydrogels2018

    • Author(s)
      S. Sornkamnerd, M.K. Okajima, K. Matsumura, T. Kaneko
    • Journal Title

      ACS Appl. Mater. Interfaces

      Volume: 10 Issue: 51 Pages: 44834-44843

    • DOI

      10.1021/acsami.8b15825

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Surface-selective control of cell-orientation on cyanobacterial liquid crystalline gels2018

    • Author(s)
      S. Sornkamnerd, M.K. Okajima, K.Matsumura, T. Kaneko
    • Journal Title

      ACS Omega

      Volume: 3 Issue: 6 Pages: 6554-6559

    • DOI

      10.1021/acsomega.7b02027

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of Functional Bionanocomposites using Cyanobacterial Polysaccharides2018

    • Author(s)
      M.K. Okajima, S. Sornkamnerd, T. Kaneko
    • Journal Title

      Chem. Rec.

      Volume: 18 Issue: 7-8 Pages: 1-12

    • DOI

      10.1002/tcr.201700074

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Micelle-mediated self-assembly of microfibers bridging millimeter-scale gap to form three-dimensional-ordered polysaccharide membranes2018

    • Author(s)
      Kosuke Okeyoshi, Takeshi Shinhama, Kulisara Budpud, Gargi Joshi, Maiko K. Okajima, Tatsuo Kaneko
    • Journal Title

      Langmuir

      Volume: 34 Issue: 46 Pages: 13965-13970

    • DOI

      10.1021/acs.langmuir.8b03116

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Formation of Polysaccharide Membranes by Splitting of Evaporative Air-LC Interface,2018

    • Author(s)
      K. Okeyoshi, G. Joshi, M.K. Okajima, T. Kaneko,
    • Journal Title

      Adv. Mater. Interfaces

      Volume: 5 Issue: 3 Pages: 1701219-1701219

    • DOI

      10.1002/admi.201701219

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Tough and Porous Hydrogels Preapred by Simple Lyopgilization of LC gels2017

    • Author(s)
      S. Sornkamnerd, M. K. Okajima, T. Kaneko
    • Journal Title

      ACS Omega

      Volume: 2 Issue: 8 Pages: 5304-5314

    • DOI

      10.1021/acsomega.7b00602

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-allergic and Profilaggrin (ProFLG)-mRNA Expression Modulatory Effects of Sacran2017

    • Author(s)
      N.R.Ngatu, K.Motoyama, Y.Nishimura, M.K.Okajima, R.Hirota, T.Higashi, S.Lee, H.Arima, M.Ikeda, S.Nojima, T.Kaneko
    • Journal Title

      Int. J. Biol. Macromol.

      Volume: 105 Pages: 1532-1538

    • DOI

      10.1016/j.ijbiomac.2017.05.049

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Drying-induced self-similar assembly of megamolecular polysaccharides through nano and submicron layering2017

    • Author(s)
      K. Okeyoshi, G. Joshi, S. Rawat, S. Sornkamnerd, K. Amornwachirabodee, M. K. Okajima, M. Ito, S. Kobayashi, K. Higashimine, Y.i Oshima, T. Kaneko
    • Journal Title

      Langmuir

      Volume: in press Issue: 20 Pages: 4954-4959

    • DOI

      10.1021/acs.langmuir.7b00107

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Methods for the self-integration of megamolecular biopolymers on the drying air-LC interface.2017

    • Author(s)
      K. Okeyoshi, K. Osada, M. K. Okajima, T. Kaneko
    • Journal Title

      Journal of Visualized Experiments

      Volume: 122 Issue: 122

    • DOI

      10.3791/55274

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Directional control of diffusion and swelling in megamolecular polysaccharide hydrogels2016

    • Author(s)
      G. Joshi, K. Okeyoshi, M. K. Okajima, T. Kaneko
    • Journal Title

      Soft Matter

      Volume: 12 Issue: 25 Pages: 5515-5518

    • DOI

      10.1039/c6sm00971a

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Snaking/Twisting Fibers Formation of Cyanobacterial Supra-Polysaccharides in Drying Process2019

    • Author(s)
      Kulisara Budpud, Kosuke Okeyoshi, Maiko Okajima, Tatsuo Kanek
    • Organizer
      Japan-India symposium
    • Related Report
      2018 Annual Research Report
  • [Presentation] Drying Induced Self-assembly of Megamolecular Polysaccharides from Planara versus Linear Air-LC Interfaces2019

    • Author(s)
      Gargi Joshi, Kosuke Okeyoshi, Maiko Okajima, Tatsuo Kaneko
    • Organizer
      Japan-India symposium
    • Related Report
      2018 Annual Research Report
  • [Presentation] Snaking/Twisting Fibers Formation of Cyanobacterial Supra-Polysaccharides in Drying Process2019

    • Author(s)
      Kulisara Budpud, Kosuke Okeyoshi, Maiko Okajima, Tatsuo Kaneko
    • Organizer
      Spring 2019 ACS National Meeting & Exposition
    • Related Report
      2018 Annual Research Report
  • [Presentation] Self-assembled Deposits of LC Polysaccharide obtained in Confined Space by Manipulating Temperature and Concentration2018

    • Author(s)
      Gargi Joshi, Kosuke Okeyoshi, Tatsuo Kaneko
    • Organizer
      第67回 高分子討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Snaking/Twisting Fibers Formation of Cyanobacterial Supra-Polysaccharides in Natural Drying Process2018

    • Author(s)
      Kulisara Budpud, Kosuke Okeyoshi, Maiko Okajima, Tatsuo Kaneko
    • Organizer
      第67回 高分子討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Evaporation Induced Self-assembly of Sacran through Planar and Linear Air-LC Interfaces2018

    • Author(s)
      Gargi Joshi, Kosuke Okeyoshi, Maiko Okajima, Tatsuo Kaneko
    • Organizer
      サクラン研究会年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Micrometer-Scale Twisting Fibers of Cyanobacterial Supra-Polysaccharides (Sacran)2018

    • Author(s)
      Kulisara Budpud; Kosuke Okeyoshi; Maiko K. Okajima; Tatsuo Kaneko
    • Organizer
      JAIST World Conference (JWC) 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Splitting of meniscus at air-LC interface of high moecualr weight polysaccharide and its theoretical evaluation2018

    • Author(s)
      Gargi Joshi, Kosuke Okeyoshi, Maiko Okajima, Tatsuo Kaneko
    • Organizer
      255th ACS National Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 究極のマイクロリアクタが 生産する超液晶性多糖類2017

    • Author(s)
      金子達雄
    • Organizer
      日本薬学会第137年会 一般シンポジウムS16 スイゼンジノリ由来多糖類サクランの魅力
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 超高分子多糖類サクランの幾何構造:マイロファバーねじれ2017

    • Author(s)
      Kulisara Budpud; Kosuke Okeyoshi; Maiko K. Okajima; Tatsuo Kaneko
    • Organizer
      第6回JACI/GSCシンポジウム
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sacran Scaffolds with Micro patterned Structures for Cell Alignment Controlled2017

    • Author(s)
      Saranyoo Sornkamnerd, 岡島 麻衣子, 松村 和明, 桶葭 興資, 金子 達雄
    • Organizer
      第6回JACI/GSCシンポジウム
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Geometric Microstructures of Supra -Polysaccharides, Polysaccharides, Sacran Sacran : Micrometer2017

    • Author(s)
      Kosuke Okeyoshi, Maiko Okajima, Tatsuo Kaneko
    • Organizer
      FiMPART’17
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Partition phenomenon of supra-polysaccharide:orientation evaluation of membrane formation on solid-gas-liquid interface2017

    • Author(s)
      Takeshi Shinhama, Kosuke Okeyoshi, Maiko Okajima, Tatsuo Kaneko
    • Organizer
      Satellite Symposium "Japan-South-East Asia Collaboration Hub of Bioplastics Study" JSPS-Core-to-Core Program
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Partition phenomenon of supra-polysaccharide:orientation evaluation of membrane formation on solid-gas-liquid interface2017

    • Author(s)
      Takeshi Shinhama, Kosuke Okeyoshi, Maiko Okajima, Tatsuo Kaneko
    • Organizer
      第66回 高分子討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] Controlled cell extension on micro-patterned surface of sacran hydrogels2017

    • Author(s)
      Saranyoo Sornkamnerd, Maiko K. Okajima, Kazuaki Matsumura, Kosuke Okeyoshi, and Tatsuo Kaneko
    • Organizer
      第66回 高分子討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] Natural supra-polysaccharide partitions geometric spaces in drying environment2017

    • Author(s)
      Kosuke Okeyoshi, Maiko Okajima, Tatsuo Kaneko
    • Organizer
      4th International Symposium for Green Innovation Polymers (GRIP2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Layered scaffolds for cell alignment controlling2017

    • Author(s)
      Saranyoo Sornkamnerd, Maiko K. Okajima, Kazuaki Matsumura, Kosuke Okeyoshi, and Tatsuo Kaneko
    • Organizer
      The 6th Asian Symposium on Advanced Materials: Chemistry, Physics & Biomedicine of Functional and Novel Materials
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Meniscus Splitting at the Gas-LC Interface in Drying Process of Megamolecular Polysaccharides2017

    • Author(s)
      Gargi Joshi, Kosuke Okeyoshi, Maiko K. Okajima, Tatsuo Kaneko
    • Organizer
      第66回 高分子討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] Sacran for cell engineering applications2017

    • Author(s)
      Saranyoo Sornkamnerd, Maiko K. Okajima, Kazuaki Matsumura, Kosuke Okeyoshi, and Tatsuo Kaneko
    • Organizer
      第 9回サクラン研究会 年次学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Microfibers Twisting of Supra-Polysaccharides, Sacran in Drying Process2017

    • Author(s)
      Kulisara Budpud; Kosuke Okeyoshi; Maiko K. Okajima; Tatsuo Kaneko
    • Organizer
      第 9回サクラン研究会 年次学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Preparation of super-anisotropic swelling sacran hydrogels by two-step cross-linking2017

    • Author(s)
      Kittima Amornwachirabodee, Maiko Okajima, Tatsuo Kaneko
    • Organizer
      第 9回サクラン研究会 年次学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Geometric Microstructures of Supra-Polysaccharides, Sacran: Micrometer-Scale Twisting Fibers2017

    • Author(s)
      Kulisara Budpud; Kosuke Okeyoshi; Maiko K. Okajima; Tatsuo Kaneko
    • Organizer
      CSJ KINKI
    • Related Report
      2017 Research-status Report
  • [Presentation] サクランの超・高分子性2016

    • Author(s)
      金子達雄
    • Organizer
      第8回 サクラン研究会年次大会
    • Place of Presentation
      熊本大学薬学部宮本記念館(熊本県熊本市)
    • Year and Date
      2016-10-01
    • Related Report
      2016 Research-status Report
    • Invited
  • [Book] スイゼンジノリとサクランの魅力2017

    • Author(s)
      金子達雄 共同執筆
    • Total Pages
      180
    • Publisher
      熊日出版
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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