Push / Pull non-equivalence of cells in the microchannel
| Project/Area Number |
16K14197
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Intelligent mechanics/Mechanical systems
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| Research Institution | Osaka University |
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Principal Investigator |
Kaneko Makoto 大阪大学, 工学研究科, 教授 (70224607)
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| Project Period (FY) |
2016-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | MEMS / 細胞操作 / 細胞計測 / 細胞制御 / 細胞変形能 / マイクロ流路 / Push/Pull非等価性 |
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| Outline of Final Research Achievements |
We constructed an experimental system where it is composed of a microfluidic chip including a narrow channel whose diameter is even smaller than a cell to be tested, an actuator for changing a pressure either at the entrance or at the exist of narrow channel, a pressure sensor for measuring the pressure in the channel, a high speed vision for observing the cell to be tested, and a micro scope for enlarging the cell. A pressure servo system was also designed for changing the pressure in the channel. In order to observe the effect coming from osmotic pressure, we changed the NaCl density of liquid with 0.6%, 0.7%, and 0.8%, respectively, so that we may examine the effect of NaCl density. Experimental results showed that the cell nose which is the length of cell entering into the narrow channel is generally longer under pulling than under pushing. Also, it is shorter under low NaCl density than under high NaCl density.
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Report
(2 results)
Research Products
(10 results)
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[Presentation] On-Chip Cell Gym2017
Author(s)
M. Horade, M. Kaneko, C. D. Tsai, H. Ito, N. Higashino, T. Akai, U. Yokoyma, Y. Ishikawa, S. Sakuma and F. Arai
Organizer
The 30th IEEE Conference on Micro Electro Mechanical Systems (MEMS2017)
Place of Presentation
Las Vegas, USA
Year and Date
2017-01-22
Related Report
Int'l Joint Research
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