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Push / Pull non-equivalence of cells in the microchannel

Research Project

Project/Area Number 16K14197
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionOsaka University

Principal Investigator

Kaneko Makoto  大阪大学, 工学研究科, 教授 (70224607)

Project Period (FY) 2016-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
KeywordsMEMS / 細胞操作 / 細胞計測 / 細胞制御 / 細胞変形能 / マイクロ流路 / Push/Pull非等価性
Outline of Final Research Achievements

We constructed an experimental system where it is composed of a microfluidic chip including a narrow channel whose diameter is even smaller than a cell to be tested, an actuator for changing a pressure either at the entrance or at the exist of narrow channel, a pressure sensor for measuring the pressure in the channel, a high speed vision for observing the cell to be tested, and a micro scope for enlarging the cell. A pressure servo system was also designed for changing the pressure in the channel. In order to observe the effect coming from osmotic pressure, we changed the NaCl density of liquid with 0.6%, 0.7%, and 0.8%, respectively, so that we may examine the effect of NaCl density. Experimental results showed that the cell nose which is the length of cell entering into the narrow channel is generally longer under pulling than under pushing. Also, it is shorter under low NaCl density than under high NaCl density.

Report

(2 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (10 results)

All 2017 2016

All Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 4 results) Presentation (6 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Transfer Function of Macro-Micro Manipulation on a PDMS Microfluidic Chip2017

    • Author(s)
      K. Mizoue, K. Teramura, C.-H. D. Tsai, and M. Kaneko
    • Journal Title

      Micromachines

      Volume: 8 Issue: 3 Pages: 80-80

    • DOI

      10.3390/mi8030080

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Red Blood Cell Responses during a Long-Standing Load in a Microfluidic Constriction2017

    • Author(s)
      M. Horade, C.-H. D. Tsai, H. Ito, and M. Kaneko
    • Journal Title

      Micromachines

      Volume: 8 Issue: 4 Pages: 100-100

    • DOI

      10.3390/mi8040100

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Gravity-Based Precise Cell Manipulation System Enhanced by In-Phase Mechanism2016

    • Author(s)
      K. Mizoue, M. H. Phan, C.-H. D. Tsai, M. Kaneko, J. Kang, and W. K. Chung
    • Journal Title

      Micromachines

      Volume: 7 Issue: 7 Pages: 116-116

    • DOI

      10.3390/mi7070116

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] An on-chip RBC deformability checker significantly improves velocity-deformation correlation2016

    • Author(s)
      C.-H. D. Tsai, J. Tanaka, M. Kaneko, M. Horade, H. Ito, T. Taniguchi, T. Ohtani, and Y. Sakata
    • Journal Title

      Micromachines

      Volume: 7 Issue: 10 Pages: 176-176

    • DOI

      10.3390/mi7100176

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Observation of Cell Pinball Through High Speed Switching Between Reflection Interference and Phase Contrast2017

    • Author(s)
      R. Murakami, A. Yamamoto, H. Ito, C. D. Tsai, M. Horade, M. Tanaka and M. Kaneko
    • Organizer
      The 30th IEEE Conference on Micro Electro Mechanical Systems (MEMS2017)
    • Place of Presentation
      Las Vegas, USA
    • Year and Date
      2017-01-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] On-Chip Cell Gym2017

    • Author(s)
      M. Horade, M. Kaneko, C. D. Tsai, H. Ito, N. Higashino, T. Akai, U. Yokoyma, Y. Ishikawa, S. Sakuma and F. Arai
    • Organizer
      The 30th IEEE Conference on Micro Electro Mechanical Systems (MEMS2017)
    • Place of Presentation
      Las Vegas, USA
    • Year and Date
      2017-01-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Buckling of RBC Under Positive and Negative Driving Pressure in a Microchannel2016

    • Author(s)
      C. D. Tsai, M. H. Phan and M. Kaneko
    • Organizer
      The 27th International Symposium on Micro-Nano Mechatronics and Human Science (MHS2016)
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2016-11-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Unexpected Beads Alignment in a Microfluidic Channel2016

    • Author(s)
      C. D. Tsai, M. H. Phan, K. Mizoue and M. Kaneko
    • Organizer
      IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS2016)
    • Place of Presentation
      Daejeon, Korea
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] “Chameleon Effect” of Rbc under Loading in Micro-Fluidic Channel2016

    • Author(s)
      M. Horade, C. D. Tsai, H. Ito, M. Tanaka and M. Kaneko
    • Organizer
      the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS16)
    • Place of Presentation
      Dublin, Ireland
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cell Sweeper for Microfluidic Cavity2016

    • Author(s)
      C. D. Tsai and M. Kaneko
    • Organizer
      the 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS16)
    • Place of Presentation
      Dublin, Ireland
    • Year and Date
      2016-10-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2018-03-22  

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