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Development of "large but small" caged carriers using nanoparticles as building blocks

Research Project

Project/Area Number 16K14468
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Reaction engineering/Process system
Research InstitutionThe University of Tokyo

Principal Investigator

Ohta Seiichi  東京大学, 大学院医学系研究科(医学部), 助教 (40723284)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsナノ粒子 / アッセンブリ / ビルディングブロック / DDS / ドラッグデリバリー / 集合体 / 有機半導体ポリマー / 環境応答性 / イメージング / ナノ材料 / ナノバイオ / 自己組織化 / 高次構造
Outline of Final Research Achievements

While nanoparticles with the diameter of ca. 100 nm are preferable for efficient tumor accumulation, their diameter needs to be single nm for renal clearance. For overcoming this size dilemma, in this study, we developed nanoparticle assembly with the diameter of ca. 100 nm using gold and semiconducting polymer fluorescent nanoparticles as building blocks. The formed assemblies were disassembled in response to tumor environment, which is expected to enable efficient renal clearance. By encapsulating photosensitizers, their tumor-specific activation of photo- and antitumor effect was demonstrated.

Academic Significance and Societal Importance of the Research Achievements

非生分解性ナノ粒子の腫瘍への集積と対外への排泄の両立は、医療分野での応用において共通した課題であった。本研究で開発された手法はビルディングブロックの粒子の種類によらず適用可能であると考えられるため、機能性ナノ粒子を画像診断や薬物送達などに応用していく上で、汎用的なプラットフォームとして発展していくことが今後期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2019 2018 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Book (1 results)

  • [Journal Article] Characterizing the protein corona of sub-10 nm nanoparticles2019

    • Author(s)
      2.Dylan Glancy, Yuwei Zhang, Jamie L. Y. Wu, Ben Ouyang, Seiichi Ohta, and Warren C. W. Chan
    • Journal Title

      Journal of Controlled Release

      Volume: - Pages: 102-110

    • DOI

      10.1016/j.jconrel.2019.04.023

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 腫瘍環境特異的に活性を発現する光増感剤封入有機半導体ポリマーナノ粒子/金ナノ粒子集積体の開発2019

    • Author(s)
      田中伸明・伊藤大知・太田誠一
    • Organizer
      化学工学会 第84年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 光線力学的療法のための有機半導体蛍光ポリマーを用いた新規光増感剤封入ナノ粒子の開発2019

    • Author(s)
      田中伸明・伊藤大知・太田誠一
    • Organizer
      東京大学医学部附属病院先端医療シーズフォーラム2019
    • Related Report
      2018 Annual Research Report
  • [Presentation] 粒子形状による生体との相互作用制御を志向した新規医用微粒子の開発2019

    • Author(s)
      太田誠一
    • Organizer
      化学工学会 第84年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 光線力学的療法のための有機半導体ポリマーナノ粒子の作製と活性のオン/オフ制御2018

    • Author(s)
      田中伸明・伊藤大知・太田誠一
    • Organizer
      化学工学会室蘭大会 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] ナノ粒子の精密設計による患部へ送達効率向上試み2017

    • Author(s)
      太田誠一
    • Organizer
      日本薬学会関東支部 第42回学術講演会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 貧溶媒添加法による光増感剤封入有機半導体ポリマーナノ粒子の合成2017

    • Author(s)
      田中伸明・伊藤大知・太田誠一
    • Organizer
      化学工学会第83年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Nanoparticle Assemblies with Dynamic Structual Change for Imaging/Drug Delivery2016

    • Author(s)
      Seiichi Ohta
    • Organizer
      Frontiers 2016 Symposium
    • Place of Presentation
      EPFL, Lausanne, Switzerland
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Dynamic nanoparticle assemblies for biomedical applications2016

    • Author(s)
      Seiichi Ohta
    • Organizer
      The 22nd Symposium of Young Asian Biological Engineers’Community (YABEC 2016)
    • Place of Presentation
      Miyazaki SEAGAIA Resort, Miyazaki
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] News Letter No. 46 新規医用ナノ粒子の創製とその集合体化による機能制御2017

    • Author(s)
      太田誠一
    • Total Pages
      6
    • Publisher
      日本化学工学会 バイオ部会
    • Related Report
      2017 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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