Development of "large but small" caged carriers using nanoparticles as building blocks
| Project/Area Number |
16K14468
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Reaction engineering/Process system
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Ohta Seiichi 東京大学, 大学院医学系研究科(医学部), 助教 (40723284)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ナノ粒子 / アッセンブリ / ビルディングブロック / DDS / ドラッグデリバリー / 集合体 / 有機半導体ポリマー / 環境応答性 / イメージング / ナノ材料 / ナノバイオ / 自己組織化 / 高次構造 |
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| Outline of Final Research Achievements |
While nanoparticles with the diameter of ca. 100 nm are preferable for efficient tumor accumulation, their diameter needs to be single nm for renal clearance. For overcoming this size dilemma, in this study, we developed nanoparticle assembly with the diameter of ca. 100 nm using gold and semiconducting polymer fluorescent nanoparticles as building blocks. The formed assemblies were disassembled in response to tumor environment, which is expected to enable efficient renal clearance. By encapsulating photosensitizers, their tumor-specific activation of photo- and antitumor effect was demonstrated.
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| Academic Significance and Societal Importance of the Research Achievements |
非生分解性ナノ粒子の腫瘍への集積と対外への排泄の両立は、医療分野での応用において共通した課題であった。本研究で開発された手法はビルディングブロックの粒子の種類によらず適用可能であると考えられるため、機能性ナノ粒子を画像診断や薬物送達などに応用していく上で、汎用的なプラットフォームとして発展していくことが今後期待される。
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Report
(4 results)
Research Products
(10 results)
