Neuronal circuit mechanisms in prepulse inhibition
| Project/Area Number |
16K14579
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Osaka University (2018)
Kyoto University (2016-2017) |
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Principal Investigator |
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| Research Collaborator |
MACPHERSON Tom
MORITA Makiko
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 統合失調症 / モデルマウス / ドーパミン / マイクロRNA / オートファジー / 大脳皮質 / 大脳皮質前頭野 / 大脳基底核 / 神経科学 / 脳・神経 / 脳神経疾患 / トランスレーショナルリサーチ / 生理学 |
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| Outline of Final Research Achievements |
We have analyzed behavioral abnormality of miR-124-1 heterozygous mice, and found abnormal prepulse inhibition and increased expression of dopamine D2 receptor in the prefrontal cortex of miR-124-1 heterozygous mice. We also found abnormal prepulse inhibition and p62 accumulation in the pyramidal neuron of the prefrontal cortex in Ulk2 heterozygous mice.
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| Academic Significance and Societal Importance of the Research Achievements |
統合失調症は複数の遺伝要因と環境要因の相互作用によって発症する複雑性疾患であり、非常に異種性の高い疾患群としての性質を持つ。そのため、共通した神経生理学的指標として確立しているプレパルスインヒビションに着目し、分子・神経回路機構を解明することは、統合失調症病態を新しい視点から解明するもので、治療法開発につながることが期待できる。
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Report
(4 results)
Research Products
(73 results)
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[Journal Article] miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation.2019
Author(s)
Kozuka T, Omori Y, Watanabe S, Tarusawa E, Yamamoto H, Chaya T, Furuhashi M, Morita M, Sato T, Hirose S, Ohkawa Y, Yoshimura Y, Hikida T, Furukawa T.
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Journal Title
Sci Rep.
Volume: Mar 5;9(1)
Issue: 1
Pages: 3445-3445
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Network mechanisms of hippocampal laterality, place coding, and goal-directed navigation.2017
Author(s)
Kitanishi,T., Ito,H.T., Hayashi,Y., Shinohara,Y., Mizuseki,K., Hikida,T.
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Journal Title
J. Physiol Sci.
Volume: 67
Issue: 2
Pages: 247-258
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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