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Development of a rapid diagnostic for detecting single base mutation related to viral drug-resistance

Research Project

Project/Area Number 16K14651
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Medical genome science
Research InstitutionOsaka University

Principal Investigator

Kaihatsu Kunihiro  大阪大学, 産業科学研究所, 特任准教授(常勤) (70419464)

Research Collaborator TAKENAKA Aya  
Project Period (FY) 2016-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords遺伝子 / 核酸 / 一塩基多型 / 薬剤耐性 / 遺伝子診断 / ウイルス / バイオテクノロジー / 蛋白質
Outline of Final Research Achievements

Current virus detection from clinical sample relies on immunochromatography that captures and detects its target viral protein by gold nanoparticle-conjugate antibody. On the other hand, we have established a method to capture the target viral gene within the viral particle by short oligonucleotide and visualized the gene using gold nanoparticles.
In this study, we succeeded to distinguish a drug-resistance of influenza virus by improving the sequence specificity of short oligonucleotide with a simple chemical modification. We further visually distinguished drug-resistant and drug-sensitive influenza virus on a membrane by our chemically-modified nucleic acid.

Report

(2 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (2 results)

All 2017

All Presentation (1 results) Book (1 results)

  • [Presentation] 化学修飾ペプチド核酸を用いたウイルスのゲノム検出2017

    • Author(s)
      開發邦宏、原田絵美、加藤修雄
    • Organizer
      日本化学会 第97春季年会、
    • Place of Presentation
      慶応大学
    • Year and Date
      2017-03-20
    • Related Report
      2016 Annual Research Report
  • [Book] 実験医学2017

    • Author(s)
      開發邦宏
    • Total Pages
      1
    • Publisher
      羊土社
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2018-03-22  

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