Research Project
Grant-in-Aid for Challenging Exploratory Research
Retrotransposons are the repetitive element interspersed throughout the genome. They have been regarded as one of the causes for chromosome configuration changes. However, the molecular mechanisms lying behind the changes have been poorly understood. In this study, we identified the involvement of retrotransposon RNA in the chromosome configuration changes. Previously, we have demonstrated, by using a model assay in fission yeast, that a canonical stress-induced cellular program imposed the retrotransposon-mediated chromosomal configuration changes. We showed here that the known transcription-coupled facilitation mechanism of homologous chromosome pairing during meiosis also contributed to the chromosome configuration changes achieved through the retrotransposons. This uncovers a common ground between the chromosome configuration changes and meiotic recombination.
All 2017 2016 Other
All Journal Article (1 results) (of which Peer Reviewed: 1 results, Open Access: 1 results, Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results, Invited: 2 results) Book (1 results) Remarks (1 results)
PLoS Genetics
Volume: 13 Issue: 2 Pages: e1006606-e1006606
10.1371/journal.pgen.1006606
120006697213
http://www.fbs.osaka-u.ac.jp/labs/ishii/index.html
