Regulation of retrotransposon RNA that facilitates recombination-mediated chromosome reorganization
Project/Area Number |
16K14670
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Molecular biology
|
Research Institution | Osaka University |
Principal Investigator |
ISHII Kojiro 大阪大学, 生命機能研究科, 特任准教授(常勤) (40360276)
|
Project Period (FY) |
2016-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
Keywords | ゲノム / 染色体 / トランスポゾン / RNA / 動原体 / セントロメア / 遺伝子 |
Outline of Final Research Achievements |
Retrotransposons are the repetitive element interspersed throughout the genome. They have been regarded as one of the causes for chromosome configuration changes. However, the molecular mechanisms lying behind the changes have been poorly understood. In this study, we identified the involvement of retrotransposon RNA in the chromosome configuration changes. Previously, we have demonstrated, by using a model assay in fission yeast, that a canonical stress-induced cellular program imposed the retrotransposon-mediated chromosomal configuration changes. We showed here that the known transcription-coupled facilitation mechanism of homologous chromosome pairing during meiosis also contributed to the chromosome configuration changes achieved through the retrotransposons. This uncovers a common ground between the chromosome configuration changes and meiotic recombination.
|
Report
(2 results)
Research Products
(8 results)
-
[Journal Article] The intron in centromeric noncoding RNA facilitates RNAi-mediated formation of heterochromatin.2017
Author(s)
Mutazono, M., Morita, M., Tsukahara, C., Chinen, M., Nishioka, S., Yumikake, T., Dohke, K., Sakamoto, M., Ideue, T., Wakayama, J.I., Ishii, K., Tani, T.
-
Journal Title
PLoS Genetics
Volume: 13
Issue: 2
Pages: e1006606-e1006606
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
[Presentation] 染色体の異数性に対する初期応答2016
Author(s)
大野悠子、細田一史、久保田佳乃、石井浩二郎
Organizer
第68回日本細胞生物学会大会
Place of Presentation
京都テルサ(京都府京都市)
Year and Date
2016-06-15
Related Report
Invited
-
-