| Project/Area Number |
16K14693
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Musashino University (2017)
The University of Tokyo (2016) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
福山 征光 東京大学, 大学院薬学系研究科(薬学部), 講師 (20422389)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 栄養応答 / TRIM-NHL / NANOS / 線虫 / シグナル伝達 / 食餌環境 / RNA結合タンパク質 / 細胞情報伝達機構 |
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| Outline of Final Research Achievements |
In animals, the nervous system is derived from neural stem and progenitor cells. These cells dynamically shuttle between the activated and quiescent states. During the former state, neural stem and progenitor cells actively divide and differentiate to produce neurons. On the other hand, these cells stay dormant during the latter. Better understanding the mechanism that regulates the balance between these two states is believed to contribute to development of regenerative medicine and elucidation of aging process. Using the nematode worm, C. elegans as an experiment system, this study found that nhl-2 and nos-1 act in the sensory and interneurons to remotely maintain the quiescent state of neural progenitor cells. These findings raise the possibility that sensing odors and tastes may affect neurogenesis.
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