| Project/Area Number |
16K14701
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Tadashi Suzuki 国立研究開発法人理化学研究所, 糖鎖代謝学研究チーム, チームリーダー (90345265)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 血清 / 遊離糖鎖 / 肝臓 / シアリル糖鎖 / バイオマーカー / 遊離N型糖鎖 / 疾患マーカー |
|---|
| Outline of Final Research Achievements |
Studies were carried out on the sialyl free glycans newly identified in animal sera. The structures of major free glycans from several mammails were determined. Changes of structures for free glycans during the various developmental stages of calf sera were also analyzed. Based on the structural information, it was hypothesized that these sialyl glycans may be secreted from liver, and their structures may reflect the repertoir of glycogenes expressed in this tissue. Furthermore, structures of serum free glycans were compared between sera of liver cancer patients and those of healthy control. It was found that the amount of major disialo, biantennary glycans were significantly increased in sera of liver cancer patients. This result raised the possibility that the serum free glycans could be utilized as a possible biomarker to indicate the pathophysiological conditions of liver.
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