Toward establishing a new method for structural biology by using ionic liquid
| Project/Area Number |
16K14771
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphology/Structure
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| Research Institution | Ube National College of Technology |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | イオン液体 / 電子顕微鏡 / 形態観察 / 走査型電子顕微鏡 / 蒸着 |
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| Outline of Final Research Achievements |
By taking advantages of ionic liquid properties such as high electron conductivity and low vapor pressure, we have aimed to develop a new sample preparation method for electron microscopy.
Ionic liquid was used to dry biological samples in a place of a conventional way like critical point drying or freeze-dry method. Our results suggest that a sample preparation by ionic liquid well preserves fine structures in biological sample at nm to um order.
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| Academic Significance and Societal Importance of the Research Achievements |
生命科学は、新しいイメージング技術の登場によって大きく進展してきた。本研究の特徴は、電顕による構造解析をより身近にすることであり、特殊な技能や装置を必要としない。そのため、生命科学分野に限らず、食品・製薬産業への応用も期待できる。また、本研究は、近年登場したイオン液体の新しい利用法でもあり、化学と生命科学の融合を目指した新しい挑戦でもある。
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Report
(4 results)
Research Products
(11 results)
