| Project/Area Number |
16K14924
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMOMURA Yoshiharu 名古屋大学, 大学院生命農学研究科, 教授
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アミノ酸 / 心臓 / 分岐鎖アミノ酸 |
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| Outline of Final Research Achievements |
In this study, we investigated the importance of BCAA (Branched chain amino acid) for maintaining heart function using the mice in which BCAAs are decreased by enhanced degradation of BCAA specifically in heart and skeletal muscle (BDK-mKO mice). There was no significant difference in heart weight between control and BDK-mKO mice at young age, however, the middle-aged BDK-mKO mice, especially in the case of feeding high-fat diet, showed significantly increased heart weight and cardiac hypertrophy-related genes which were decreased by BCAA administration.
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