Protective effect of dietary carotenoid on the skin
| Project/Area Number |
16K14926
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
真鍋 祐樹 京都大学, 農学研究科, 助教 (20730104)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 食品機能 / 光老化 / シフォナキサンチン / カロテノイド / 皮膚 / 緑藻 / 食品 / 栄養学 / 生理活性 / 老化 |
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| Outline of Final Research Achievements |
We evaluated the effect of dietary siphonaxanthin derived from green algae on skin photoaging in UVA-irradiated hairless mice. After chronic UVA exposure, a significant increase in trans-epidermal water loss and wrinkle formation in the dorsal skin caused by UVA was observed, and dietary sihonaxanthin significantly suppressed these photoaging features. Siphonaxanthin and its metabolites were found in the skin of siphonaxanthin-fed mice. It was suggested that dietary siphonaxanthin could affect the decrease of natural moisturizing factors in the epidermis and the increase of matrix metalloprotease in the dermis by UVA irradiation because of the changes of mRNA expressions in the skin. Our results indicate that dietary siphonaxanthin accumulates in the skin and appears to prevent the photoaging.
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Report
(3 results)
Research Products
(4 results)
