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Protective effect of dietary carotenoid on the skin

Research Project

Project/Area Number 16K14926
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionKyoto University

Principal Investigator

SUGAWARA Tatsuya  京都大学, 農学研究科, 教授 (70378818)

Co-Investigator(Kenkyū-buntansha) 真鍋 祐樹  京都大学, 農学研究科, 助教 (20730104)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords食品機能 / 光老化 / シフォナキサンチン / カロテノイド / 皮膚 / 緑藻 / 食品 / 栄養学 / 生理活性 / 老化
Outline of Final Research Achievements

We evaluated the effect of dietary siphonaxanthin derived from green algae on skin photoaging in UVA-irradiated hairless mice. After chronic UVA exposure, a significant increase in trans-epidermal water loss and wrinkle formation in the dorsal skin caused by UVA was observed, and dietary sihonaxanthin significantly suppressed these photoaging features. Siphonaxanthin and its metabolites were found in the skin of siphonaxanthin-fed mice. It was suggested that dietary siphonaxanthin could affect the decrease of natural moisturizing factors in the epidermis and the increase of matrix metalloprotease in the dermis by UVA irradiation because of the changes of mRNA expressions in the skin. Our results indicate that dietary siphonaxanthin accumulates in the skin and appears to prevent the photoaging.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2017

All Journal Article (1 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] 藻類由来カロテノイドの生理作用2017

    • Author(s)
      菅原達也、真鍋祐樹
    • Journal Title

      機能性食品と薬理栄養

      Volume: 11 Pages: 80-85

    • Related Report
      2017 Annual Research Report
  • [Presentation] UVA照射ヘアレスマウスの皮膚光老化に与えるシフォナキサンチン経口摂取の影響2017

    • Author(s)
      橋本夏希、中山千華、真鍋祐樹、菅原達也
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脂質成分の皮膚機能保全作用2017

    • Author(s)
      菅原達也
    • Organizer
      第71回日本栄養・食糧学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 緑藻シフォナキサンチンによる皮膚光老化抑制効果2017

    • Author(s)
      橋本夏希、中山千華、真鍋祐樹、菅原達也
    • Organizer
      第31回カロテノイド研究談話会
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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