| Project/Area Number |
16K15021
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal production science
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| Research Institution | Tohoku University |
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Principal Investigator |
Aso Hisashi 東北大学, 農学研究科, 教授 (50241625)
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| Co-Investigator(Kenkyū-buntansha) |
北澤 春樹 東北大学, 農学研究科, 准教授 (10204885)
野地 智法 東北大学, 農学研究科, 准教授 (10708001)
渡邊 康一 東北大学, 農学研究科, 助教 (80261494)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | セロトニン / 褐色脂肪細胞 / THP1 / エネルギー代謝 / 抗肥満作用 / 抗肥満効果 |
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| Outline of Final Research Achievements |
Mice were fed a chow (Ch) diet or a high fat (F) diet and orally administrated with serotonin (5-HT) every morning between the ages of 5 and 26 weeks. Mice on the F diet gained significantly more weight than the Ch fed mice. In order to identify the target tissues of the effect of 5-HT on energy metabolism, we focused on brawn adipose tissue. PGC-1 is a master regulator that promotes mitochondrial biogenesis and an activity of uncoupling protein (UCP) 1 in brawn adipose tissue. 5-HT increased the expressions of PGC-1-a, b, c and UCP1. Brawn adipose tissue had higher expressions of 5HTR2A, 2B and 7. Mice were pre-treated with several 5-HTR antagonists at 30 min before 5-HT injection. We revealed that 5-HT increased the mRNA expressions of PGC-1and UCP1 through 5-HTR2A and 7.
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