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Serotonin improves high fat diet induced obesity in mice by the activations of PGC-1 alpha and UCP1 through 5-HTR2A and 7

Research Project

Project/Area Number 16K15021
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Animal production science
Research InstitutionTohoku University

Principal Investigator

Aso Hisashi  東北大学, 農学研究科, 教授 (50241625)

Co-Investigator(Kenkyū-buntansha) 北澤 春樹  東北大学, 農学研究科, 准教授 (10204885)
野地 智法  東北大学, 農学研究科, 准教授 (10708001)
渡邊 康一  東北大学, 農学研究科, 助教 (80261494)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsセロトニン / 褐色脂肪細胞 / THP1 / エネルギー代謝 / 抗肥満作用 / 抗肥満効果
Outline of Final Research Achievements

Mice were fed a chow (Ch) diet or a high fat (F) diet and orally administrated with serotonin (5-HT) every morning between the ages of 5 and 26 weeks. Mice on the F diet gained significantly more weight than the Ch fed mice. In order to identify the target tissues of the effect of 5-HT on energy metabolism, we focused on brawn adipose tissue. PGC-1 is a master regulator that promotes mitochondrial biogenesis and an activity of uncoupling protein (UCP) 1 in brawn adipose tissue. 5-HT increased the expressions of PGC-1-a, b, c and UCP1. Brawn adipose tissue had higher expressions of 5HTR2A, 2B and 7. Mice were pre-treated with several 5-HTR antagonists at 30 min before 5-HT injection. We revealed that 5-HT increased the mRNA expressions of PGC-1and UCP1 through 5-HTR2A and 7.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (43 results)

All 2018 2017 2016 Other

All Journal Article (16 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 16 results,  Open Access: 16 results,  Acknowledgement Compliant: 3 results) Presentation (24 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Immunobiotics for the bovine host: their interaction with intestinal epithelial cells and their effect on antiviral immunity.2018

    • Author(s)
      Julio Villena, Hisashi Aso, Victor P. Rutten, Hideki Takahashi, Willem Van Eden and Haruki Kitazawa
    • Journal Title

      Frontiers in Immunology

      Volume: 9 Pages: 326-326

    • DOI

      10.3389/fimmu.2018.00326

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of a novel mechanism of action of bovine IgG antibodies specific for Staphylococcus aureus2018

    • Author(s)
      Furukawa Mutsumi、Yoneyama Hiroshi、Hata Eiji、Iwano Hidetomo、Higuchi Hidetoshi、Ando Tasuke、Sato Mika、Hayashi Tomohito、Kiku Yoshio、Nagasawa Yuya、Niimi Kanae、Usami Katsuki、Ito Kumiko、Watanabe Kouichi、Nochi Tomonori、Aso Hisashi
    • Journal Title

      Veterinary Research

      Volume: 49 Issue: 1 Pages: 22-22

    • DOI

      10.1186/s13567-018-0517-y

    • NAID

      120006798140

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of a moderate-fat diet that is enriched with fish oil on intestinal lipid absorption in a senescence-accelerated prone mouse model2018

    • Author(s)
      Yamamoto Kazushi、Iwagaki Yui、Watanabe Kouichi、Nochi Tomonori、Aso Hisashi、Tsuduki Tsuyoshi
    • Journal Title

      Nutrition

      Volume: 50 Pages: 26-35

    • DOI

      10.1016/j.nut.2017.10.015

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exopolysaccharides from Lactobacillus delbrueckii OLL1073R-1 modulate innate antiviral immune response in porcine intestinal epithelial cells2017

    • Author(s)
      Paulraj Kanmani, Leonardo Albarra2018.00326in, Hisakazu Kobayashi, Hikaru Iida, Ryoya Komatsu, A.K.M. Humayun Kober, Wakako Ikeda-Ohtsubo, Yoshihito Suda, Hisashi Aso, Seiya Makino, Hiroshi Kano, Tadao Saito, JulioVillen, Haruki Kitazawa
    • Journal Title

      Molecular Immunology

      Volume: 93 Pages: 253-265

    • DOI

      10.1016/j.molimm.2017.07.009

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transcriptomic analysis of the innate antiviral immune response in porcine intestinal epithelial cells: influence of immunobiotic lactobacilli.2017

    • Author(s)
      Albarracin, L., H. Kobayashi, H. Iida, N. Sato, T. Nochi, H. Aso, S. Salva, S. Alvarez, H. Kitazawa, J. Villena
    • Journal Title

      Front. Immunol.

      Volume: 8(57) Pages: 1-15

    • DOI

      10.3389/fimmu.2017.00057

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Development of an in vitro immunobiotic evaluation system against rotavirus infection in bovine intestinal epitheliocytes2017

    • Author(s)
      Kobayashi, H., P. Kanmani, T. Ishizuka, A. Miyazaki, J. Soma, L. Albarracin, Y. Suda, T. Nochi, H. Aso, N. Iwabuchi, J-z. Xiao, T. Saito, J. Villena, H. Kitazawa
    • Journal Title

      Beneficial Microbes

      Volume: 8 (2) Issue: 2 Pages: 309-321

    • DOI

      10.3920/bm2016.0155

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modulation of porcine intestinal epitheliocytes immunetranscriptome response by Lactobacillus jensenii TL2937: finding new biomarkers for the selection of antiinflammatory immunobiotics.2016

    • Author(s)
      Kobayashi, H., L. Albarracin, N. Sato, P. Kanmani, AKM H. Kober, W. Ikeda-Ohtsubo, Y. Suda, T. Nochi, H. Aso, S. Makino, H. Kano, S. Ohkawara, T. Saito, J. Villena, H. Kitazawa
    • Journal Title

      Beneficial Microbes, Benef Microbes

      Volume: 7 Issue: 5 Pages: 769-782

    • DOI

      10.3920/bm2016.0095

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lactogenic hormones alter cellular and extracellular microRNA expression in bovine mammary epithelial cell culture2016

    • Author(s)
      Susumu Muroya, Tatsuro Hagi, Ataru Kimura, Hisashi Aso, Masatoshi Matsuzaki and Masaru Nomura
    • Journal Title

      Journal of Animal Science and Biotechnology

      Volume: 7 Issue: 1 Pages: 8-8

    • DOI

      10.1186/s40104-016-0068-x

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dynamic Metabolic Regulation by a Chromosome Segment from a Wild Relative During Fruit Development in a Tomato Introgression Line, IL8-32016

    • Author(s)
      Hiroki Ikeda, Tomoki Shibuya, Shunsuke Imanishi, Hisashi Aso, Manabu Nishiyama and Yoshinori Kanayama
    • Journal Title

      Plant and Cell Physiology

      Volume: 57 Issue: 6 Pages: 1257-1270

    • DOI

      10.1093/pcp/pcw075

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics of pig lines generated by crossing an MPS pulmonary lesion selected Landrace line and a highly immune capacity selected Large White line.2016

    • Author(s)
      Borjigin L, Shimazu T, Katayama Y, Watanabe K, Kitazawa H, Roh SG, Aso H, Katoh K, Uchida T, Suda Y, Sakuma A, Nakajo M, Suzuki K
    • Journal Title

      Animal Science Journal

      Volume: 印刷中 Issue: 8 Pages: 972-981

    • DOI

      10.1111/asj.12529

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunogenic properties of Landrace pigs selected for resistance to mycoplasma pneumonia of swine.2016

    • Author(s)
      Borjigin L, Shimazu T, Katayama Y, Watanabe K, Kitazawa H, Roh S, Aso H, Katoh K, Uchida T, Suda Y, Sakuma A, Nakajo M and Suzuki K
    • Journal Title

      Animal Science Journal

      Volume: 印刷中 Issue: 5 Pages: 638-645

    • DOI

      10.1111/asj.12471

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunoregulatory effects triggered by immunobiotic Lactobacillus jensenii TL2937 strain involve efficient phagocytosis in porcine antigen presenting cells.2016

    • Author(s)
      Kohichiro Tsukida, Takuya Takahashi, Hikaru Iida, Paulraj Kanmani, Yoshihito Suda, Tomonori Nochi, Shuichi Ohwada, Hisashi Aso, Sou Ohkawara, Seiya Makino, Hiroshi Kano, Tadao Saito, Julio Villena, and Haruki Kitazawa
    • Journal Title

      BMC Immunology

      Volume: 17 Issue: 1 Pages: 1-18

    • DOI

      10.1186/s12865-016-0160-1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immunogenic properties of Landrace pigs selected for resistance to mycoplasma pneumonia of swine.2016

    • Author(s)
      Borjigin L, Shimazu T, Katayama Y, Li M, Satoh T, Watanabe K, Kitazawa H, Roh S, Aso H, Katoh K, Uchida T, Suda Y, Sakuma A, Nakajo M and Suzuki K
    • Journal Title

      Animal Science Journal

      Volume: 印刷中 Issue: 3 Pages: 321-329

    • DOI

      10.1111/asj.12440

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 2.Immunobiotic Bifidobacteria Strains Modulate Rotavirus Immune Response in Porcine Intestinal Epitheliocytes via Pattern Recognition Receptor Signaling.2016

    • Author(s)
      Ishizuka T, Kanmani P, Kobayashi H, Miyazaki A, Soma J, Suda Y, Aso H, Nochi T, Iwabuchi N, Xiao JZ, Saito T, Villena J, Kitazawa H.
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 3 Pages: 1-19

    • DOI

      10.1371/journal.pone.0152416

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cyclophilin A is a new M cell marker of bovine intestinal epithelium.2016

    • Author(s)
      Tetsuya Hondo , Shunsuke Someya , Yuya Nagasawa , Shunsuke Terada, Hitoshi Watanabe, Xiangning Chen, Kouichi Watanabe, Shyuichi Ohwada, Haruki Kitazawa, Michael T. Rose, Tomonori Nochi, Hisashi Aso
    • Journal Title

      Cell and Tissue Research

      Volume: 364 Issue: 3 Pages: 585-597

    • DOI

      10.1007/s00441-015-2342-1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Simultaneous analysis of serotonin, tryptophan and tryptamine levels in common fresh fruits and vegetables in Japan using fluorescence HPLC2016

    • Author(s)
      Jahidul Islam, Hitoshi Shirakawa, Thomas Kim Nguyen, Hisashi Aso, Michio Komai
    • Journal Title

      Food Bioscience

      Volume: 13 Pages: 56-59

    • DOI

      10.1016/j.fbio.2015.12.006

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 末梢セロトニンの褐色脂肪細胞活性化による抗肥満作用2018

    • Author(s)
      田口輝明・甲藤士郎・田中孝太朗・庄 涛・吉村 梢・渡邊康一・野地智法・麻生 久
    • Organizer
      日本畜産学会第124回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 初産牛における乳汁中の体細胞数と炎症誘起因子シクロフィリンA濃度との相関解析2018

    • Author(s)
      海野 剛・浦川めぐみ・庄 涛・田中孝太朗・吉村 梢・佐藤佑子・伊藤 愛・小林宏子・渡邊康一・野地智法・麻生 久
    • Organizer
      日本畜産学会第124回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ブタにおける二次リンパ組織の形態形成機序の解明2018

    • Author(s)
      古川睦実・伊藤 駿・鈴木俊一・淵本大一郎・渡邊康一・麻生 久・野地智法
    • Organizer
      日本畜産学会第124回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of immune and microbial environments is independently regulated in the mammary gland2017

    • Author(s)
      Niimi K., Usami K., Aso H., Nochi T.
    • Organizer
      日本免疫学会第46回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Important role of the immunological network between large intestine and mammary gland in breastfeeding2017

    • Author(s)
      Usami K., Niimi K., Kamioka M., Kiyono H., Aso H., Nochi T.
    • Organizer
      日本免疫学会第46回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] プロバイオティクス枯草菌によるウシ乳房炎の発症軽減効果2017

    • Author(s)
      浦川めぐみ・佐藤秀俊・庄 涛・田口輝明・海野 剛・田中孝太朗・甲藤士郎・吉村 梢・小林宏子・伊藤 愛・高田直和・芦田延久・大友直樹・渡邊康一・野地智法・麻生 久
    • Organizer
      日本乳房炎研究会第22回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 二次リンパ組織の形態形成に関するブタ胎仔を用いた組織学的研究2017

    • Author(s)
      古川睦実、伊藤 駿、盛田彰太郎、鈴木俊一、淵本大一郎、中井美智子、大西 彰、新實香奈枝、宇佐美克紀、佐々木志保、渡邊康一、麻生 久、野地智法
    • Organizer
      日本獣医学会第160回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] X-SCIDモデルブタ(IL2Rg欠損ブタ)の各種臓器内に認められるT細胞およびB細胞分布に関する組織学的研究2017

    • Author(s)
      伊藤 駿、古川睦実、盛田彰太郎、鈴木俊一、淵本大一郎、中井美智子、大西 彰、新實香奈枝、宇佐美克紀、佐々木志保、渡邊康一、麻生 久、野地智法
    • Organizer
      日本獣医学会第160回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effects of common microbial ligands for TLRs on adipogenesis and inflammation in porcine adipocytes2017

    • Author(s)
      井形愛美・K.AKM Humayun・Tada A.・A. Leonardo・Ikeda-Ohtsubo W.・Aso H.・Yoda K.・Miyazawa K.・He Fang・Saito T.・Villena J.・Kitazawa H.
    • Organizer
      日本畜産学会第123回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Dispensable role of indigenous bacteria in developing the mammary gland functions2017

    • Author(s)
      Niimi K.・Usami K.・Furukawa M.・Sasaki S.・Ito S.・Banba Y.・Watanabe K.・Aso H.・Nochi T.
    • Organizer
      日本畜産学会第123回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 末梢セロトニンの骨格筋線維型移行および代謝亢進作用の解明2017

    • Author(s)
      甲藤士郎・田口輝明・田中孝太朗・庄 涛・吉村 梢・渡邊康一・野地智法・麻生 久
    • Organizer
      日本畜産学会第123回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of advanced evaluation system of anti-disease immunobiotics2017

    • Author(s)
      Komatsu R.・Iida H.・K.AKM Humayun・Albarracin Leonardo 3・Suda Y.・Ikeda-Ohtsubo W.・Aso H.・Iwabuchi N.・Xiao Jin-zhong・Saito T.・Villena J.・Kitazawa H.
    • Organizer
      日本畜産学会第123回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 授乳期特有の乳腺免疫の発達に関わるT細胞の役割とは2017

    • Author(s)
      宇佐美克紀・新實香奈枝・古川睦実・佐々木志保・伊藤 駿・馬場柚里・渡邊康一・麻生 久・野地智法
    • Organizer
      東北畜産学会第67回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 授乳期の乳腺の機能形成おける役割2017

    • Author(s)
      佐々木志保・新實香奈枝・宇佐美克紀・古川睦実・伊藤 駿・馬場柚里・渡邊康一・麻生 久・野地智法
    • Organizer
      東北畜産学会第67回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス腸管上皮M 細胞におけるアルドラーゼA受容体の探索2017

    • Author(s)
      鈴木 京・長澤裕哉・田中孝太朗・庄 涛・田口輝明・北澤春樹・渡邊康一・野地智法・麻生 久
    • Organizer
      日本畜産学会第122回大会
    • Place of Presentation
      神戸市、神戸大学
    • Related Report
      2016 Research-status Report
  • [Presentation] 乳腺と大腸をつなぐ免疫ネットワークの解明2017

    • Author(s)
      宇佐美克紀・新實香奈枝・古川睦実・佐々木志保・伊藤 駿・渡邊康一・麻生 久・野地智法
    • Organizer
      日本畜産学会第122回大会
    • Place of Presentation
      神戸市、神戸大学
    • Related Report
      2016 Research-status Report
  • [Presentation] ウシ血中樹状細胞の精製法確立と枯草菌給与による活性化機構の解明2017

    • Author(s)
      庄 涛・浦川めぐみ・鈴木 京・田口輝明・佐藤秀俊・高田直和・及川俊徳・小林宏子・伊藤 愛・芦田延久・今林寛和・渡邊康一・野地智法・麻生 久
    • Organizer
      日本畜産学会第122回大会
    • Place of Presentation
      神戸市、神戸大学
    • Related Report
      2016 Research-status Report
  • [Presentation] 枯草菌の給与が乳牛の血中栄養因子および免疫因子に与える影響2017

    • Author(s)
      浦川めぐみ・佐藤秀俊・庄 涛・鈴木 京・田口輝明・小林宏子・伊藤 愛・高田 直和・及川俊徳・芦田延久・今林寛和・渡邊康一・野地智法・麻生 久
    • Organizer
      日本畜産学会第122回大会
    • Place of Presentation
      神戸市、神戸大学
    • Related Report
      2016 Research-status Report
  • [Presentation] 黄色ブドウ球菌特異的IgG 抗体はSortase A非依存的に細胞増殖を阻害する2017

    • Author(s)
      古川睦実・米山 裕・秦 英司・安藤太助・林 智人・菊 佳男・長澤裕哉・渡邊康一・麻生 久・野地智法
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      仙台市、仙台国際センター
    • Related Report
      2016 Research-status Report
  • [Presentation] 黄色ブドウ球菌(SA)の死菌接種によって産生されるポリクローナル抗体はSAに対する増殖阻害効果を有する2016

    • Author(s)
      古川睦実・米山 裕・秦 英司・岩野英知・樋口豪紀・安藤太助・佐藤美佳・林 智人・菊 佳男・長澤裕哉・新實香奈枝・宇佐美克紀・佐々木志保・伊藤 駿・渡邊康一・麻生 久・野地智法
    • Organizer
      第6回家畜感染症学会
    • Place of Presentation
      福岡市、九州大学西新プラザ
    • Related Report
      2016 Research-status Report
  • [Presentation] フローサイトメトリーを用いた授乳期の乳腺に認められるIgA産生形質細胞の性状解析2016

    • Author(s)
      宇佐美克紀・新實香奈枝・古川睦実・藤田勇気・阿部未来・渡邊康一・麻生 久・野地智法
    • Organizer
      第159回日本獣医学会
    • Place of Presentation
      藤沢市、日本大学生物資源科学部
    • Related Report
      2016 Research-status Report
  • [Presentation] 褐色脂肪細胞の活性化による経口セロトニンの抗肥満作用2016

    • Author(s)
      田口輝明・日高湧介・海野 剛・對木陽淳・陳 香凝・北澤春樹・渡邊康一・野地智法・麻生 久
    • Organizer
      第66回東北畜産学会大会
    • Place of Presentation
      盛岡市、いわて県民情報交流センター
    • Related Report
      2016 Research-status Report
  • [Presentation] 枯草菌給与によるウシ分娩前後における血中樹状細胞の機能解析2016

    • Author(s)
      庄 涛・浦川めぐみ・佐藤秀俊・高田直和・及川俊徳・小林宏子・伊藤 愛・芦田延久・今林寛和・渡邊康一・野地智法・麻生 久
    • Organizer
      第66回東北畜産学会大会
    • Place of Presentation
      盛岡市、いわて県民情報交流センター
    • Related Report
      2016 Research-status Report
  • [Presentation] 黄色ブドウ球菌のin vitroでの増殖阻害を可能にするウシポリクローナル抗体の作製2016

    • Author(s)
      古川睦実・米山 裕・秦 英司・岩野英知・樋口豪紀・安藤太助・佐藤美佳・林 智人・菊 佳男・長澤裕哉・新實香奈枝・宇佐美克紀・佐々木志保・伊藤 駿・渡邊康一・麻生 久・野地智法
    • Organizer
      第66回東北畜産学会大会
    • Place of Presentation
      盛岡市、いわて県民情報交流センター
    • Related Report
      2016 Research-status Report
  • [Book] Energy homeostasis by peripheral serotonin2017

    • Author(s)
      Hitoshi Watanabe, Michael Rose, Yoshinori Kanayama, Hitoshi Shirakawa and Hisashi Aso
    • Total Pages
      305
    • Publisher
      InTech Team
    • ISBN
      9789535152903
    • Related Report
      2017 Annual Research Report
  • [Remarks] 東北大学大学院農学研究科機能形態学分野

    • URL

      http://www.agri.tohoku.ac.jp/keitai/index-j.html

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
  • [Remarks] 東北大学大学院農学研究科食と農免疫国際教育研究センター

    • URL

      http://www.agri.tohoku.ac.jp/cfai/index.html

    • Related Report
      2017 Annual Research Report 2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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