Regulation of ovarian fuctions through exosome-mediated inter-organ communications
| Project/Area Number |
16K15052
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Sugiura Koji 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (20595623)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 卵巣卵胞 / エクソソーム / ブタ / 卵巣 |
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| Outline of Final Research Achievements |
Extra-cellular vesicles, called exosomes, contain several bioactive materials, and are now considered as novel mediators of cell-to-cell communications. This study aimed to test a possibility that exosomes produced in organs other than ovaries regulate ovarian function. The results were as follows.
1. RNA-sequencing of transcripts in porcine follicular exosomes revealed a possibility that some of follicular exosomes were originated from organs other than ovaries.
2. Follicular exosomes promoted FSH signaling in ovarian somatic cells in culture.
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Report
(3 results)
Research Products
(3 results)
