Regulation of ovarian fuctions through exosome-mediated inter-organ communications

Research Project

Project/Area Number	16K15052
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Integrative animal science
Research Institution	The University of Tokyo
Principal Investigator	Sugiura Koji 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (20595623)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	卵巣卵胞 / エクソソーム / ブタ / 卵巣
Outline of Final Research Achievements	Extra-cellular vesicles, called exosomes, contain several bioactive materials, and are now considered as novel mediators of cell-to-cell communications. This study aimed to test a possibility that exosomes produced in organs other than ovaries regulate ovarian function. The results were as follows. 1. RNA-sequencing of transcripts in porcine follicular exosomes revealed a possibility that some of follicular exosomes were originated from organs other than ovaries. 2. Follicular exosomes promoted FSH signaling in ovarian somatic cells in culture.

Report

(3 results)