| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
In development of many oxidative disease, change of redox reaction have been reported to be involved. Here, in this study, we aimed to develop a detection probe for reductive stress. We herein designed a mitochondrial targeting profluorescent nitroxide probe for the detection of reductive stress. We demonstrated that this probe can detect an excess amount of electron donating compound in living cell, which causes the mitochondrial reductive stress.
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