Identification and functional analysis of a mast cell lysophosphatidylserine receptor.
| Project/Area Number |
16K15113
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
Aoki Junken 東北大学, 薬学研究科, 教授 (20250219)
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | マスト細胞 / 脱顆粒 / リゾホスファチジルセリン / 受容体 / 作動薬 |
|---|
| Outline of Final Research Achievements |
It has been suggested that a receptor for lysophosphatidylserine (LysoPS), a kind of lysophospholipid mediators, is present on mast cells. Mast cells are immune cells involved in the development of allergy. Several preceding studies have shown that LysoPS strongly up-regulated the antigen-IgE-induced degranulation of mast cells. However, the molecular identification as well as the biochemical characterization of the mast cell LysoPS remained to be done. The present research aimed to identify this LysoPS receptor. In this study, we found that mast cells from fawn-hooded rat, a kind of rat strains, did not degranulate in response to LysoPS. Since mast cells derived from the fawn-hooded rat degranulated in response to a calcium ionophore as was observed in mast cells from Wister strain rats, it is strongly suggested that the fawn-hooded rats are deficient in the LysoPS receptor. A new strategy to identify LysoPS receptor by genetic analysis was proposed.
|
Report
(3 results)
Research Products
(5 results)
-
-
-
[Journal Article] Conformational Constraint of the Glycerol Moiety of Lysophosphatidylserine, an Emerging Lysophospholipid Mediator, Affords Compounds with Receptor Subtype Selectivity2016
Author(s)
Sejin Jung, Asuka Inoue, Sho Nakamura, Takayuki Kishi, Akiharu Uwamizu, Misa Sayama, Masaya Ikubo, Yuko Otani, Kuniyuki Kano, Kumiko Makide, Junken Aoki, Tomohiko Ohwada
-
Journal Title
The Journal of Medicinal Chemistry
Volume: 59
Issue: 8
Pages: 3750-3776
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
-
