| Project/Area Number |
16K15119
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Research Collaborator |
TAKAHASHI Hakuo 関西医科大学, 名誉教授
OKAMURA Hitoshi 京都大学, 大学院薬学研究科, 教授
KUROIWA Sayaka 京都大学, 薬学部, 学部生
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| Project Period (FY) |
2016-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 高血圧 / 視床下部 / アルドステロン / 血圧 / Cyp11b2 / RAAS / 副腎 / cyp11b2 |
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| Outline of Final Research Achievements |
Hypertension is a causative factor for ischemic heart disease, stroke, and kidney failure. Thus, its remedy is clinically important. It is widely recognized that a negative feedback mechanism of the renin - angiotensin - aldosterone system (RAAS) in the peripheral organs controls a blood pressure level; when blood pressure reaches a high level, renin secretion from the kidney is inhibited and blood pressure will be lowered. In this study, however, I found that expression of aldosterone synthase is elevated in the brain of mice fed with high salt diet. This increase is a sharp contrast with that in periphery. From this result, it is suggested that RAAS forms a positive feedback mechanism in the brain, and normalizing the activity level of RAAS in the brain is effective for treating hypertension.
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