• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Physiological role of hypothalamic aldosterone synthase in high-salt diet-induced hypertension

Research Project

Project/Area Number 16K15119
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biological pharmacy
Research InstitutionKyoto University

Principal Investigator

Yamaguchi Yoshiaki  京都大学, 薬学研究科, 助教 (30467427)

Research Collaborator TAKAHASHI Hakuo  関西医科大学, 名誉教授
OKAMURA Hitoshi  京都大学, 大学院薬学研究科, 教授
KUROIWA Sayaka  京都大学, 薬学部, 学部生
Project Period (FY) 2016-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords高血圧 / 視床下部 / アルドステロン / 血圧 / Cyp11b2 / RAAS / 副腎 / cyp11b2
Outline of Final Research Achievements

Hypertension is a causative factor for ischemic heart disease, stroke, and kidney failure. Thus, its remedy is clinically important. It is widely recognized that a negative feedback mechanism of the renin - angiotensin - aldosterone system (RAAS) in the peripheral organs controls a blood pressure level; when blood pressure reaches a high level, renin secretion from the kidney is inhibited and blood pressure will be lowered. In this study, however, I found that expression of aldosterone synthase is elevated in the brain of mice fed with high salt diet. This increase is a sharp contrast with that in periphery. From this result, it is suggested that RAAS forms a positive feedback mechanism in the brain, and normalizing the activity level of RAAS in the brain is effective for treating hypertension.

Report

(2 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (2 results)

All 2016 Other

All Presentation (1 results) (of which Invited: 1 results) Remarks (1 results)

  • [Presentation] 時差を担う視交叉上核バソプレッシンV1a, V1b 受容体2016

    • Author(s)
      山口賀章
    • Organizer
      第16回日本抗加齢医学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Remarks] 京都大学大学院薬学研究科 医薬創成情報科学専攻 システムバイオロジー分野

    • URL

      http://www.pharm.kyoto-u.ac.jp//system-biology/

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi