Development of a ganma-tubulin targeting diketopiperazine and its study on chemical biology
| Project/Area Number |
16K15145
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ジケトピペラジン / γ-チューブリン / プリナブリン / 抗がん剤 / 水溶性プロドラック / γ―チューブリン / 薬学 / 有機化学 / 創薬化学 / チューブリン |
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| Outline of Final Research Achievements |
In this study we focus on a novel diketopiperazine (DKP) derivative "KPU-406" targeting γ-tubulin. To elucidate the function of γ-tubulin, a potential target molecule for cancer therapy, we synthesized fragment derivatives having a partial structure of KPU-406 and biotinylated derivative of KPU-406 as a chemical probe.
From now on, through determination of the interaction between obtained derivatives and γ-tubulin, it is expected that the function of γ-tubulin is elucidated, leading to the new anticancer drug development.
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Report
(3 results)
Research Products
(9 results)
