| Project/Area Number |
16K15161
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
Yagi Kiyohito 大阪大学, 薬学研究科, 教授 (70166479)
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| Co-Investigator(Kenkyū-buntansha) |
渡利 彰浩 大阪大学, 薬学研究科, 講師 (80452465)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 経皮吸収 / 表皮 / Homoharringtonine / Tight Junciton / Claudin / Homoharringtonin / Tight junciton / Tight junction / 表皮バリア / 薬学 / DDS |
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| Outline of Final Research Achievements |
In this study, we evaluated the transdermal absorption-promoting effect of Homoharringtonine (HHT) both in vitro and in vivo. HHT exhibited a transdermal absorption-promoting effect for macromolecules up to 10,000 Da in size, and reduced the expression of TJ components that are important for construction of the skin TJ barrier, including claudin-1, claudin-4, and occludin. Furthermore, HHT enhanced absorption of DNA/RNA heteroduplex oligonucleotide through skin. These findings indicated that HHT acts on the epidermal TJ barrier and may serve as a novel transdermal absorption-promoting agent that permits the passage of high-molecular-weight drugs such as biopharmaceuticals.
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