| Project/Area Number |
16K15234
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
AOE Seiichiro 大妻女子大学, 家政学部, 教授 (90365049)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アミノ酸 / マクロファージ / 炎症 / セリン / 炎症性サイトカイン |
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| Outline of Final Research Achievements |
Accumulating evidence has suggested that overnutrition-induced chronic inflammation plays an important role in the pathophysiology of the metabolic syndrome. As a molecular basis of chronic inflammation in the metabolic syndrome, sustained complex interaction between parenchymal and stromal cells results in tissue fibrosis, thereby leading to organ dysfunction. However, little is known about the molecular mechanism underlying metabolic stress-induced chronic inflammatory changes in macrophages. In this study, we tried to elucidate the role of serine metabolism in the regulation of macrophage function. Our data showed that serine metabolism is a novel mechanism of inflammatory cytokine production in macrophages.
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