Development of new technology to analyze cellular interaction between neuron and glial cells
| Project/Area Number |
16K15240
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Keio University |
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Principal Investigator |
KOHYAMA JUN 慶應義塾大学, 医学部(信濃町), 准教授 (30437511)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 細胞間相互作用 / アストロサイト / 神経変性疾患 / バイオインフォマティクス / ニューロン / 試験管内モデル / 共培養 / シグナル伝達 |
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| Outline of Final Research Achievements |
It is becoming apparent that cellular interaction between neuronal cells and glial cells contributes to pathogenesis of neurodegenerative disease. I have developed a system to analyze the transcriptome of cocultured neurons and glial cells without mechanical isolation. Using this system, I discovered unique features in neurodegenerative patient-derived astrocytes, which lead to novel therapeutic application.
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Report
(3 results)
Research Products
(1 results)
