Development of new technology to analyze cellular interaction between neuron and glial cells

Research Project

Project/Area Number	16K15240
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Pathological medical chemistry
Research Institution	Keio University
Principal Investigator	KOHYAMA JUN 慶應義塾大学, 医学部(信濃町), 准教授 (30437511)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	細胞間相互作用 / アストロサイト / 神経変性疾患 / バイオインフォマティクス / ニューロン / 試験管内モデル / 共培養 / シグナル伝達
Outline of Final Research Achievements	It is becoming apparent that cellular interaction between neuronal cells and glial cells contributes to pathogenesis of neurodegenerative disease. I have developed a system to analyze the transcriptome of cocultured neurons and glial cells without mechanical isolation. Using this system, I discovered unique features in neurodegenerative patient-derived astrocytes, which lead to novel therapeutic application.

Report

(3 results)