ex vivo imaging of cerebral amyloid angiopathy and its associated lesions using micro-MRI
| Project/Area Number |
16K15246
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Mie University |
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Principal Investigator |
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| Research Collaborator |
Hashizume Yoshio
Niwa Atsushi
Shindo Akihiro
Ishikawa Hidehiro
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | マイクロMRI / 脳アミロイド血管症 / 剖検脳 / アミロイドβ / 毛細血管 |
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| Outline of Final Research Achievements |
Amyloid β is a protein causing Alzheimer’s disease, and deposits not only in the neuropil but also in the blood vessels which leads to cerebral amyloid angiopathy (CAA). As a result of vascular amyloid β deposit, various microvascular lesions such as microbleeds and microinfarctions may occur, but the exact pathomechanism of lesion development remained uncertain. In the present study, we applied micro-MRI technique to autopsied brains which enabled us to obtain radiological images of microvascular lesion due to CAA, and further delineated the pathological aspects of these images. In addition, we delineated contribution of neuroinflammation to the loss of vascular integrity, because in the sites of microvascular lesions, there was marked accumulation of inflammatory molecules including complement proteins.
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| Academic Significance and Societal Importance of the Research Achievements |
脳アミロイド血管症は高率にアルツハイマー病に合併するが、それ自体も認知症の原因となる。従来の診断技術では脳アミロイド血管症を臨床的に診断するためには脳生検が必要であったが、本研究の結果から、脳アミロイド血管症を示唆する画像所見に対応する病理変化が明らかになった。この結果、必ずしも脳生検を行わなくてもMRIの画像所見から脳アミロイド血管症を診断する新たな診断技術の可能性が示された。
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Comparative Analysis of Cortical Microinfarcts and Microbleeds using 3.0-Tesla Postmortem Magnetic Resonance Images and Histopathology.2017
Author(s)
Niwa A, Ii Y, Shindo A, Matsuo K, Ishikawa H, Taniguchi A, Takase S, Maeda M, Sakuma H, Akatsu H, Hashizume Y, Tomimoto H.
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Journal Title
J Alzheimers Dis.
Volume: 59
Issue: 3
Pages: 951-959
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Background and distribution of lobar microbleeds in cognitive dysfunction.2017
Author(s)
Matsuyama H, Ii Y, Maeda M, Umino M, Ueda Y, Tabei KI, Kida H, Satoh M, Shindo A, Taniguchi A, Takahashi R, Tomimoto H1
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Journal Title
Brain Behav.
Volume: 7
Issue: 11
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Astrocyte-Derived Pentraxin 3 Supports Blood-Brain Barrier Integrity Under Acute Phase of Stroke2016
Author(s)
Shindo A, Maki T, Mandeville ET, Liang AC, Egawa N, Itoh K, Itoh N, Borlongan M, Holder JC, Chuang TT, McNeish JD, Tomimoto H, Lok J, Lo EH, Arai K.
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Journal Title
Stroke
Volume: 47
Issue: 4
Pages: 1094-100
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 血管性認知症診療の新展開2016
Author(s)
冨本秀和
Organizer
第35回日本認知症学会学術集会
Place of Presentation
東京国際フォーラム(東京都・千代田区）
Year and Date
2016-12-01
Related Report
Invited
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