Mechanisms underlying the deficiency of oral immunity and its effect on systemic organ network
| Project/Area Number |
16K15252
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Komatsu Noriko 東京大学, 大学院医学系研究科(医学部), 助教 (20553358)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 口腔免疫 / 骨破壊 / T細胞 / 炎症性骨破壊 / 口腔内細菌 / 自己免疫疾患 / 免疫学 |
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| Outline of Final Research Achievements |
Oral cavity harbors unique oral microbiota and immune system. In periodontitis, infection of pathogenic bacteria disturbs the homeostasis of oral microbiota, which eventually results in the loss of bone that is important for supporting teeth. However, the mechanism of bone loss in periodontitis has not been fully understood. In this study, we found that a novel arthritogenic T cell subset which we identified previously turned out to be the most potent bone-damaging T cells in periodontitis. Interestingly, the bone-damaging T cells contribute to the host defense by regulating the quality and quantity of oral microbiota. We identified several molecules that are specifically expressed in the bone-damaging T cells, which will contribute to establish the methods to regulate immunological association between oral cavity and remote organs by modulating local tissue destruction and the systemic host defense.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] LOX Fails to Substitute for RANKL in Osteoclastogenesis2017
Author(s)
Tsukasaki M, Hamada K, Okamoto K, Nagashima K, Terashima A, Komatsu N, Win S, Okamura T, Nitta T, Yasuda H, Penninger JM, Takayanagi H
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Journal Title
Journal of Bone and Mineral Research
Volume: 32
Issue: 3
Pages: 434-439
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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