| Project/Area Number |
16K15279
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Research Collaborator |
ONOMOTO Koji
JOGI Michihiko
SAKUMA Chiaki
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 免疫学 / RNA |
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| Outline of Final Research Achievements |
In this study, we tried to examine whether the viral RNA sensor molecule, RIG-I-like receptor (RLR), can recognize endogenous RNA(s) and trigger anti-viral innate immune responses to regulate an unknown physiological activity. Our results demonstrate that several kinds of 5’ppp-containing endogenous RNAs, which are transcribed by RNA polymerase III, induce type I interferon-activating signal in RIG-I-dependent manner, suggesting an possible importance of interaction between viral RNA sensor molecule and self-RNA.
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