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Fundamental study of systematic epidemiology in big data

Research Project

Project/Area Number 16K15354
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Epidemiology and preventive medicine
Research InstitutionTohoku University

Principal Investigator

Narita Akira  東北大学, 東北メディカル・メガバンク機構, 助教 (50459468)

Co-Investigator(Kenkyū-buntansha) 田宮 元  東北大学, 東北メディカル・メガバンク機構, 教授 (10317745)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords疫学 / ビッグデータ / 遺伝統計学 / ネットワーク理論
Outline of Final Research Achievements

The aim of the study is to establish a high-precision system for prediction of risk of disease, which is one of main components of personalized prevention and medicine, by making the maximum use of larger and larger-scale data sets.
First, the association between natural disaster-related mild physical injury and psychological distress was evaluated using a data set of the Shichigahama Health Promotion Project in cross-sectional study design. Secondly, the association between residential area and psychological distress, and that between extent of house damage and bone density were evaluated using a data set of the the Tohoku Medical Megabank Project. In addition, genetic variants associated with blood pressure were searched for in an international consortium, and a population-based genome-wide interaction analysis was conducted to detect genetic variants that modulate the effect of salt intake on blood pressure.

Academic Significance and Societal Importance of the Research Achievements

本研究で得られた一連の成果は、東日本大震災で被災した地域住民において、具体的な被災程度や内容、また性、年齢、生活習慣や、その他様々な社会的・経済的因子が、メンタルヘルスや骨密度などの健康指標とどのように関連しているか、またその結果を踏まえて、どのようなケアやその他の施策が重要かを示唆する一助となり得る。
一方で、ゲノム多型データなど、日々大規模化、多様化するデータを活用し、高血圧などの疾患やその他の形質と関連する遺伝的多様体の探索を通じて、個別化予防・医療の柱の一つである、高精度疾患発症リスク評価システムの確立につながる成果と言える。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (6 results)

  • [Journal Article] Association between mild physical injury and psychological distress: Shichigahama Health Promotion Project2018

    • Author(s)
      成田 暁・中谷直樹・中村智洋・土屋菜歩・小暮真奈・辻 一郎・寳澤 篤・富田 博秋
    • Journal Title

      Nihon Koshu Eisei Zasshi(JAPANESE JOURNAL OF PUBLIC HEALTH)

      Volume: 65 Issue: 4 Pages: 157-163

    • DOI

      10.11236/jph.65.4_157

    • NAID

      130006731377

    • ISSN
      0546-1766, 2187-8986
    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-wide analysis of polymorphism?×?sodium interaction effect on blood pressure identifies a novel 3′-BCL11B gene desert locus2018

    • Author(s)
      Hachiya Tsuyoshi、Narita Akira、Ohmomo Hideki、Sutoh Yoichi、Komaki Shohei、Tanno Kozo、Satoh Mamoru、Sakata Kiyomi、Hitomi Jiro、Nakamura Motoyuki、Ogasawara Kuniaki、Yamamoto Masayuki、Sasaki Makoto、Hozawa Atsushi、Shimizu Atsushi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 14162-14162

    • DOI

      10.1038/s41598-018-32074-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interethnic analyses of blood pressure loci in populations of East Asian and European descent2018

    • Author(s)
      Takeuchi F, Kohara K, et al.
    • Journal Title

      Nat Commun.

      Volume: 9 Issue: 1 Pages: 5052-5052

    • DOI

      10.1038/s41467-018-07345-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 遺伝因子と飲酒量の交互作用と随時血圧値の関連 -東北メディカル・メガバンク計画 地域住民コホート調査-2019

    • Author(s)
      成田 暁・中谷直樹・小暮真奈・田宮 元・中村智洋・土屋菜歩・平田 匠・丹野高三・坂田清美・菅原準一・栗山進一・辻 一郎・呉 繁夫・寳澤 篤
    • Organizer
      第29回日本疫学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 家屋損壊程度と骨梁面積率の変化量の関連:東北メディカル・メガバンク事業2018

    • Author(s)
      成田 暁・中谷直樹・中村智洋・土屋菜歩・平田 匠・小暮真奈・後岡広太郎・丹野高三・坂田清美・小原 拓・菅原準一・栗山進一・辻 一郎・呉 繁夫・寳澤 篤
    • Organizer
      第77回日本公衆衛生学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 東日本大震災後のメンタルヘルスの内陸-沿岸較差:東北メディカル・メガバンク事業2017

    • Author(s)
      成田 暁・中谷直樹・中村智洋・土屋菜歩・小暮真奈・丹野高三・佐々木亮平・高梨信之・坂田清美・富田博秋・菊谷昌浩・菅原準一・栗山進一・辻 一郎・呉 繁夫・寳澤 篤
    • Organizer
      第27回日本疫学会学術総会
    • Place of Presentation
      ベルクラシック甲府(山梨県・甲府市)
    • Year and Date
      2017-01-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 東日本大震災による家屋の被災状況と骨密度の関連:東北メディカル・メガバンク事業2017

    • Author(s)
      成田 暁・中谷直樹・中村智洋・土屋菜歩・小暮真奈・高井貴子・丹野高三・坂田清美・菊谷昌浩・菅原準一・栗山進一・辻 一郎・呉 繁夫・寳澤 篤
    • Organizer
      第76回日本公衆衛生学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] サンプル間の非独立性が関連解析に及ぼす影響の予備的検討2017

    • Author(s)
      成田 暁・中谷直樹・中村智洋・土屋菜歩・小暮真奈・田宮 元・丹野高三・菅原準一・栗山進一・辻 一郎・呉 繁夫・寳澤 篤
    • Organizer
      第28回日本疫学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 東日本大震災における外傷と心理的苦痛の関連:七ヶ浜健康増進プロジェクト2016

    • Author(s)
      成田 暁・中谷直樹・中村智洋・土屋菜歩・小暮真奈・辻 一郎・寳澤 篤・富田博秋
    • Organizer
      第75回日本公衆衛生学会総会
    • Place of Presentation
      グランフロント大阪(大阪府・大阪市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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