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A new approach to elucidate the risk of malignant lymphoma in atomic bomb survivors

Research Project

Project/Area Number 16K15358
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Epidemiology and preventive medicine
Research InstitutionNagasaki University

Principal Investigator

IWANAGA Masako  長崎大学, 医歯薬学総合研究科(医学系), 教授 (00372772)

Co-Investigator(Kenkyū-buntansha) 新野 大介  長崎大学, 医歯薬学総合研究科(医学系), 客員教授 (20426563)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords悪性リンパ腫 / malignant lymphom / 原爆被ばく者 / atomic bomb survivors / 放射線被曝 / Radiation exposure / がん登録 / cancer registry / 放射線被ばく / 病理診断 / 発症リスク / 疫学 / 放射腺被ばく
Outline of Final Research Achievements

There has been no consensus for the relationship between increased radiation exposure and the increased risk of malignant lymphoma among atomic-bomb (AB) survivors. Previous reports of AB survivors have evaluated any lymphomas only by dividing into two major groups, Hodgkin and non-Hodgkin lymphomas; therefore, information has been limited wherther there were any differences in the incidence by cell-lineage and by maturity patterns of malignant lymphoma. The present study, therefore, investigated whether there are any differences in the cell-lineage and by maturity patterns of lymphomas between general population and AB survivors based on data from the Nagasaki-prefectural cancer registry and the Nagasaki AB survivors database. As a result, we found that there was signinificant difference in the cell-linearge proportion between AB survivors and non-survivors, B-cell lymphoma was predominant for AB survivors whereas T-cell lymphoma was predominant for non-survivors.

Academic Significance and Societal Importance of the Research Achievements

放射線被曝と悪性リンパ腫発症との関連は、骨髄系腫瘍とは異なり一定の見解が得られていませんでした。そこで本研究は長崎県がん登録に登録されたリンパ系腫瘍を詳細に分類し一般集団と原爆被曝者集団で腫瘍のタイプごとに発症割合を比較しました。その結果、原爆被曝者ではB 細胞リンパ腫が多く、一般集団では T 細胞リンパ腫が多いという違いを認めました。違いの理由については今後の詳細な研究が必要です。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (15 results)

All 2019 2018 2017 2016

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (9 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results)

  • [Journal Article] Clinical and histopathological significance of PD-1 expression in cutaneous lesions of adult T-cell leukemia?lymphoma2019

    • Author(s)
      Higuchi Maho、Kuwatsuka Yutaka、Murota Hiroyuki、Iwanaga Masako、Niino Daisuke
    • Journal Title

      Pathology - Research and Practice

      Volume: 215 Issue: 1 Pages: 40-49

    • DOI

      10.1016/j.prp.2018.10.001

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 【リンパ節の非腫瘍性疾患の病理】 話題の疾患 他の医原性免疫不全に伴うリンパ増殖性疾患2017

    • Author(s)
      新野 大介
    • Journal Title

      病理と臨床

      Volume: 35 Pages: 549-553

    • Related Report
      2017 Research-status Report
  • [Journal Article] Hyperglycemia is associated with poor survival in primary central nervous system lymphoma patients.2017

    • Author(s)
      Debata A, Yoshida K, Ujifuku K, Yasui H, Kamada K, Niino D, Matsuo T
    • Journal Title

      Tumori

      Volume: 印刷中 Issue: 3 Pages: 272-278

    • DOI

      10.5301/tj.5000590

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Clinicopathologic Study of Lennert Lymphoma and Possible Prognostic Factors: The Importance of Follicular Helper T-cell Markers and the Association With Angioimmunoblastic T-cell Lymphoma.2016

    • Author(s)
      Kurita D, Miyoshi H, Yoshida N, Sasaki Y, Kato S, Niino D, Sugita Y, Hatta Y, Takei M, Makishima M, Ohshima K
    • Journal Title

      Am J Surg Pathol

      Volume: 40 Issue: 9 Pages: 1249-60

    • DOI

      10.1097/pas.0000000000000694

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical features and prognosis of patients with myelodysplastic syndromes who were exposed to atomic bomb radiation in Nagasaki2016

    • Author(s)
      Matsuo M, Iwanaga M, Kondo H, Soda M, Jo T, Horio K, Takasaki Y, Kawaguchi Y, Tsushima H, Imaizumi Y, Imanishi D, Taguchi J, Sawayama Y, Hata T, Miyazaki Y
    • Journal Title

      Cancer Science

      Volume: 107 Issue: 10 Pages: 1484-1491

    • DOI

      10.1111/cas.13025

    • NAID

      120006987207

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Smoking is a Risk Factor for Development of Adult T-cell Leukemia/Lymphoma in Japanese Human T-cell Leukemia Virus Type-1 Carriers2016

    • Author(s)
      Kondo H, Soda M, Sawada N, Inoue M, Imaizumi Y, Miyazaki Y, Iwanaga M, Tanaka Y, Mizokami M, Tsugane S
    • Journal Title

      Cancer Causes & Control

      Volume: 27 Issue: 9 Pages: 1059-1066

    • DOI

      10.1007/s10552-016-0784-8

    • NAID

      120006987206

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Incidence Pattern of Malignant Lymphoma by Cell-lineage/Cell-maturity status in Nagasaki, Japan 1985-2012: Preliminary Results.2019

    • Author(s)
      Thi My Hanh Luong, Daisuke Niino, Hisayoshi Kondo, Shiro Miura, Masahiro Nakashima, Masako Iwanaga.
    • Organizer
      NCCN 24th Annual Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Incidence of malignant lymphoma in Nagasaki Cancer registries, 1985-2012.2019

    • Author(s)
      Thi My Hanh Luong, Daisuke Niino, Hisayoshi Kondo, Shiro Miura, Masahiro Nakashima, Masako Iwanaga
    • Organizer
      第81回日本血液学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Incidence Pattern of Malignant Lymphoma by Cell-lineage/Cell-maturity status in Nagasaki, Japan 1985-2012: Preliminary Results.2019

    • Author(s)
      Thi My Hanh Luong, Daisuke Niino, Hisayoshi Kondo, Shiro Miura, Masahiro Nakashima, Masako Iwanaga.
    • Organizer
      NCCN 24th Annual Conference, Orlando, USA (2019/3/19-24)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] High PD-1 expression in cutaneous manifestations of ATL is associated with inferior outcome.2018

    • Author(s)
      新野 大介, 樋口 真帆, 鍬塚 大, 岩永 正子
    • Organizer
      第 107 回日本病理学会総会, 札幌, 日本 (2018/6/21-23)
    • Related Report
      2018 Research-status Report
  • [Presentation] Incidence patterns of multiple lymphoid malignancies: Nagasaki Cancer Registry data.2018

    • Author(s)
      Daisuke Niino, Thi My Hanh Luong, Shiro Miura, Masayuki Nakashima, Masako Iwanaga.
    • Organizer
      第80回日本血液学会学術集会, 大阪, 日本 (2018/10/12-14)
    • Related Report
      2018 Research-status Report
  • [Presentation] 2017 WHOリンパ系・骨髄系腫瘍分類改訂T/NK細胞リンパ腫の変更点2017

    • Author(s)
      新野 大介
    • Organizer
      第56会日本臨床細胞学会秋期大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Incidence Patterns of Patients with Two or More Lymphoid Malignancies in a Patient with a Prior History of Lymphoid Malignancy: A Population-Based Cancer Registry Study in Nagasaki, Japan.2017

    • Author(s)
      Iwanaga M, Niino D, Hanh Luong TM, Miura S, Nakashima M.
    • Organizer
      59th ASH (American Society of Hematology) Annual Meeting & Exposition
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 長崎大学病院における悪性リンパ腫の病理学的検討2006-2015:ATLの割合トレンド.2016

    • Author(s)
      桐原志保美,板垣亮里,岩永正子,新野大介
    • Organizer
      第3回日本HTLV-1学会学術集会
    • Place of Presentation
      鹿児島県市町村自治会館、鹿児島市、鹿児島県
    • Related Report
      2016 Research-status Report
  • [Presentation] 上五島病院における悪性リンパ腫の病理学的検討2006-2015:ATLの割合のトレンド.2016

    • Author(s)
      板垣亮里, 桐原志保美,岸川孝之,岩永正子, 新野大介
    • Organizer
      第3回日本HTLV-1学会学術集会
    • Place of Presentation
      鹿児島県市町村自治会館、鹿児島市、鹿児島県
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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