A prospective study on the association between body temperature and metabolic syndrome and cause of death in the general urban population

• Project/Area Number: 16K15365
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: KOKUBO YOSHIHIRO 国立研究開発法人国立循環器病研究センター, 病院, 医長 (20393217)
• Project Period (FY): 2016-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 腋窩体温 / 耳体温 / 追跡研究 / メタボリックシンドローム / 原死因 / 表在体温 / 深部体温 / 危険因子 / 疫学研究

Outline of Final Research Achievements

We set a hypothesis that higher body temperature is associated with future metabolic syndrome and cause of death in the general population in Japan. During the 34,646 person-years follow-up (mean 14.6 years), we observed 506 cause of death. Compared with the first quartile of axillary temperature in men, adjusted HR (95% CI) of the third and fourth quartiles of axillary temperature were 1.5 (1.1-2.0) and 1.6 (1.2-2.2) for all-cause mortality in men, respectively. Compared with 1st ear temperature in men, the adjusted-hazard rations for all-cause mortality were 1.4 (1.0-2.0), 1.5 (1.1-2.1), and 1.7 (1.2-2.3) in second, third, and forth quartile of ear temperature. Those for coronary heart study mortality were 4.2 (1.1-15.4), 4.9 (1.4-17.4), and 5.7 (1.5-20.4). The adjusted hazard ratios for cardiovascular disease mortality was 2.5 (1.2-5.0) in men. However, there was no association between body temperature and cause mortality.

Research Products

• [Journal Article] Development of a Basic Risk Score for Incident Atrial Fibrillation in a Japanese General Population: the Suita Study. (2017)
  • Author(s): Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Kusano K, Miyamoto Y.
  • Journal Title: Circ J Volume: 91
  • NAID: 130006179872
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Impact of hypertension on the lifetime risk of coronary heart disease (2016)
  • Author(s): Chowdhury Turin T, Okamura T, Raheen Afzal A, Rumana N, Watanabe M, Higashiyama A, Nakao YM, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y.
  • Journal Title: Hypertens Res Volume: ２３ Issue: 7 Pages: 548-51
  • DOI: 10.1038/hr.2016.23
  • Peer Reviewed
• [Journal Article] Hypertension and lifetime risk of stroke (2016)
  • Author(s): Turin TC, Okamura T, Afzal AR, Rumana N, Watanabe M, Higashiyama A, Nakao Y, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y
  • Journal Title: J Hypertens Volume: ３４ Issue: 1 Pages: 116-22
  • DOI: 10.1097/hjh.0000000000000753
  • Peer Reviewed
• [Journal Article] Traditional Cardiovascular Risk Factors for Incident Atrial Fibrillation (2016)
  • Author(s): Kokubo Y, Matsumoto C.
  • Journal Title: Circulation Journal Volume: 80 Issue: 12 Pages: 2415-2422
  • DOI: 10.1253/circj.CJ-16-0919
  • NAID: 130005285052
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Impact of renal function deterioration on adverse events during anticoagulation therapy using non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. (2016)
  • Author(s): Miyamoto K, Aiba T, Arihiro S, Watanabe M, Kokubo Y, Ishibashi K, Hirose S, Wada M, Nakajima I, Okamura H, Noda T, Nagatsuka K, Noguchi T, Anzai T, Yasuda S, Ogawa H, Kamakura S, Shimizu W, Miyamoto Y, Toyoda K, Kusano K.
  • Journal Title: Heart Vessels Volume: ９９
  • Peer Reviewed
• [Presentation] A Risk Score for Incident Atrial Fibrillation in General Cohort Studies in Japan: a Collaborative Meta-analysis. (2017)
  • Author(s): Kokubo Y, Imao H, Hata J, Murakoshi N, Aizawa Y, Iso H, Ninomiya T, Nakamura F, Miyamoto Y, Aonuma K, Okamura T, Tomita H, Okumura K.
  • Organizer: Symposium, the 81th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-17
• [Presentation] The Risk Factors of Incident Atrial Fibrillation Observed in the Suita Study (2017)
  • Author(s): .Kokubo Y, Watanabe M, Higashiyama A, Watanabe T, Miyamoto Y
  • Organizer: Symposium, the 81th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-17
  • Invited
• [Presentation] Increased Carotid Intima-Media Thickness Is Associated with Incident Coronary Heart Disease and Stroke in a Japanese General Population with a 12.6-year Follow-up: The Suita Study (2017)
  • Author(s): Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Takegami M, Miyamoto Y.
  • Organizer: International Stroke Conference 2017.
  • Place of Presentation: Houston, TX, U.S.A.
  • Year and Date: 2017-02-22
  • Int'l Joint Research
• [Presentation] 一般住民における心房細動罹病リスク (2017)
  • Author(s): .Kokubo Y
  • Organizer: 日本脳卒中学会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] The Development of a Risk Score for Incident Atrial Fibrillation in Japanese General Population Cohorts: a Collaborative Meta-analysis. (2016)
  • Author(s): Kokubo Y, Imao H, Hata J, Murakoshi N, Aizawa Y, Iso H, Ninomiya T, Nakamura F, Miyamoto Y, Aonuma K, Okamura T, Tomita H, Okumura K.
  • Organizer: Scientific Session 2016, American Heart Association.
  • Place of Presentation: New Orleans, Louisiana, U.S.
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] 都市部地域住民を対象とする心房細動罹病リスクスコアー作成による10年後罹病予測：吹田研究 (2016)
  • Author(s): 小久保喜弘、渡邉至、東山綾、中尾葉子、草野研吾、宮本恵宏
  • Organizer: 第39回日本高血圧学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-09-30
• [Presentation] Perspective on elderly hypertension in Asia (2016)
  • Author(s): Kokubo Y.
  • Organizer: International Soxiety of Hypertension
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-09-24
  • Int'l Joint Research / Invited
• [Presentation] Systolic Blood Pressure and Lifestyle Contributes to the Development of a Risk Score for Incident Atrial Fibrillation in the Japanese General Population: The Suita Study (2016)
  • Author(s): Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Nakamura F, Nishimura K, Takegami M, Kusano K, Miyamoto Y.
  • Organizer: Council on Hypertension 2016 Scientific Sessions of the American Heart Association
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2016-09-14
  • Int'l Joint Research
• [Presentation] Combination of Smoking and Metabolic Syndrome Components Increased the Risk of Incident Atrial Fibrillation: The Suita Study (2016)
  • Author(s): Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Watanabe T, Takegami M, Kusano K, Kamakura S, Miyamoto Y.
  • Organizer: European Society of Cardiology 2016
  • Place of Presentation: Roma, Italy.
  • Year and Date: 2016-08-26
  • Int'l Joint Research
• [Book] MISO: Healthy Japanese Cooking. (2016)
  • Author(s): Kokubo Y, Hashimoto Y.
  • Total Pages: 68
  • Publisher: Shodensha