| Project/Area Number |
16K15376
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Nagoya City University |
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Principal Investigator |
Odanaka Mizuyu 名古屋市立大学, 大学院医学研究科, 研究員 (00510281)
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| Co-Investigator(Kenkyū-buntansha) |
今井 優樹 名古屋市立大学, 大学院医学研究科, 講師 (30440936)
山崎 小百合 名古屋市立大学, 大学院医学研究科, 教授 (70567255)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 紫外線 / 制御性T細胞 / 樹状細胞 / 環境保健 |
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| Outline of Final Research Achievements |
Ultraviolet B (UVB) irradiation is known to induce immune tolerance. In this study, we investigated the roles of dendritic cells (DCs) subsets for UVB-mediated immune tolerance. We found that Langerin negative DCs but not LCs or Langerin positive dermal DCs are required for regulatory T cells (Tregs) expansion in UVB-exposed skin. Upon UVB exposure, CD11b-type Langerin negative DCs upregulated the expression of several tolerogenic genes related to Tregs function and proliferation. These results indicate that CD11b-type Langerin negative DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity.
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