The mechanisms of immune tolerance induced by Ultraviolet B-expanded regulatory T cells in the skin.
Project/Area Number |
16K15376
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Hygiene and public health
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Research Institution | Nagoya City University |
Principal Investigator |
Odanaka Mizuyu 名古屋市立大学, 大学院医学研究科, 研究員 (00510281)
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Co-Investigator(Kenkyū-buntansha) |
今井 優樹 名古屋市立大学, 大学院医学研究科, 講師 (30440936)
山崎 小百合 名古屋市立大学, 大学院医学研究科, 教授 (70567255)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 紫外線 / 制御性T細胞 / 樹状細胞 / 環境保健 |
Outline of Final Research Achievements |
Ultraviolet B (UVB) irradiation is known to induce immune tolerance. In this study, we investigated the roles of dendritic cells (DCs) subsets for UVB-mediated immune tolerance. We found that Langerin negative DCs but not LCs or Langerin positive dermal DCs are required for regulatory T cells (Tregs) expansion in UVB-exposed skin. Upon UVB exposure, CD11b-type Langerin negative DCs upregulated the expression of several tolerogenic genes related to Tregs function and proliferation. These results indicate that CD11b-type Langerin negative DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity.
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Report
(3 results)
Research Products
(8 results)
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[Presentation] The critical role of dendritic cell subset in expanding Foxp3+ regulatory T cells in the murine skin after ultraviolet B exposure.2017
Author(s)
Yamazaki, S., Nishioka, A., Kasuya, S., Odanaka, M., Hemmi, H., Imai, M., Riethmacher, D., Kaisho, T., Ohkura, N., Sakaguchi, S., Morita, A.
Organizer
LC2017 15th International Workshop on Langerhans Cells
Related Report
Int'l Joint Research
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