The mechanisms of immune tolerance induced by Ultraviolet B-expanded regulatory T cells in the skin.

• Project/Area Number: 16K15376
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: Nagoya City University
• Principal Investigator: Odanaka Mizuyu 名古屋市立大学, 大学院医学研究科, 研究員 (00510281)
• Co-Investigator(Kenkyū-buntansha): 今井 優樹 名古屋市立大学, 大学院医学研究科, 講師 (30440936) ; 山崎 小百合 名古屋市立大学, 大学院医学研究科, 教授 (70567255)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 紫外線 / 制御性T細胞 / 樹状細胞 / 環境保健

Outline of Final Research Achievements

Ultraviolet B (UVB) irradiation is known to induce immune tolerance. In this study, we investigated the roles of dendritic cells (DCs) subsets for UVB-mediated immune tolerance. We found that Langerin negative DCs but not LCs or Langerin positive dermal DCs are required for regulatory T cells (Tregs) expansion in UVB-exposed skin. Upon UVB exposure, CD11b-type Langerin negative DCs upregulated the expression of several tolerogenic genes related to Tregs function and proliferation. These results indicate that CD11b-type Langerin negative DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity.

Research Products

• [Journal Article] Ultraviolet B-induced maturation of CD11b-type Langerin-dendritic cells control the expansion of Foxp3+ regulatory T cells in the skin (2018)
  • Author(s): Yamazaki Sayuri、Odanaka Mizuyu、Nishioka Akiko、Kasuya Saori、Shime Hiroaki、Hemmi Hiroaki、Imai Masaki、Riethmacher Dieter、Kaisho Tsuneyasu、Ohkura Naganari、Sakaguchi Shimon、Morita Akimichi
  • Journal Title: J Immunol Volume: 200 Pages: 119-129
  • DOI: 10.4049/jimmunol.1701056
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] The critical role of dendritic cell subset in expanding Foxp3+ regulatory T cells in the murine skin after ultraviolet B exposure. (2017)
  • Author(s): Yamazaki, S., Nishioka, A., Kasuya, S., Odanaka, M., Hemmi, H., Imai, M., Riethmacher, D., Kaisho, T., Ohkura, N., Sakaguchi, S., Morita, A.
  • Organizer: LC2017 15th International Workshop on Langerhans Cells
  • Int'l Joint Research
• [Presentation] Does Juzen-Taiho-Tohave immunosuppressive effect? (2016)
  • Author(s): Ken Kanno, Mizuyu Odanaka, Masaki Imai, Akiko Nishioka, Saori Kasuya, Mitsuhiko Nose, Hiroaki Henmi, Tsuneyasu Kaisho, Akimichi Morita, Sayuri Yamazaki
  • Organizer: 第45回日本免疫学会学術集会
  • Place of Presentation: 沖縄コンベンションセンター（沖縄県、宜野湾市）
  • Year and Date: 2016-12-05
• [Presentation] Phenotype analysis of Foxp3+CD4+ regulatory T cells in the skin after Ultra Violet B(UVB) exposure (2016)
  • Author(s): ODANAKA Mizuyu, YAMAZAKI Sayuri, NISHIOKA Akiko, KASUYA Saori, TAKAYAMA Shoryu, IMAI Masaki, MORITA Akimichi
  • Organizer: Cold Spring Harbor Conference Asia
  • Place of Presentation: 淡路夢舞台国際会議場（兵庫県、淡路市）
  • Year and Date: 2016-10-03
  • Int'l Joint Research
• [Presentation] The complement anaphylatoxin C5ades Arg still induce the acute inflammatory responce (2016)
  • Author(s): Masaki IMAI, Mizuyu ODANAKA, Shoryu TAKAYAMA,Rieko Ohta, Sayuri YAMAZAKI
  • Organizer: Cold Spring Harbor Conference Asia
  • Place of Presentation: 淡路夢舞台国際会議場（兵庫県、淡路市）
  • Year and Date: 2016-10-03
  • Int'l Joint Research
• [Presentation] Does Juzen-Taiho-To show therapeutic effect in Imiquimod-induced psoriatic mice? (2016)
  • Author(s): Ken Kanno, Masaki Imai, Mizuyu Odanaka, Akiko Nishioka, Saori Kasuya, Mitsuhiko Nose, Hiroaki Henmi, Tsuneyasu Kaisho, Akimichi Morita, Sayuri Yamazaki
  • Organizer: Cold Spring Harbor Conference Asia
  • Place of Presentation: 淡路夢舞台国際会議場（兵庫県、淡路市）
  • Year and Date: 2016-10-03
  • Int'l Joint Research
• [Presentation] Ultraviolet B Expands Skin-Homing Thymus-derived Foxp3+ CD4+ Regulatory T Cells (2016)
  • Author(s): Sayuri Yamazaki, Mizuyu Odanaka, Akiko Nishioka, Saori Kasuya,Masaki Imai, Osamu Taguchi, Akimichi Morita
  • Organizer: Cold Spring Harbor Conference Gene Expression& Signaling in the Immune System
  • Place of Presentation: NewYork (U.S.A)
  • Year and Date: 2016-04-26
  • Int'l Joint Research
• [Remarks]
  • URL: http://www.med.nagoya-cu.ac.jp/immunol.dir/index.html